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1. academic.oup.com › genetics › articleWingless Signaling: A Genetic Journey from Morphogenesis to ...

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   Apr 1, 2018 · Wingless, the fly homolog of the mammalian Wnt oncoproteins, plays a central role in pattern generation during development. Much of what we know about the pathway was learned from genetic and molecular experiments in Drosophila melanogaster, and the core pathway works the same way in vertebrates.

   • Author: Amy Bejsovec

   • Publish Year: 2018

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3. www.nature.com › articles › s41467/021/25785-zPegasus, a small extracellular peptide enhancing short-range ...

   www.nature.com › articles › s41467/021/25785-z

   Sep 27, 2021 · Amongst these is the secreted cell-signalling protein DWnt1/Wingless (Wg), which has sequential expression patterns and functions in wing development 12, 13, culminating in the patterning of...

   • Author: Emile G. Magny, Ana Isabel Platero, Sarah A. Bishop, Sarah A. Bishop, Jose I. Pueyo, Daniel Aguilar-...

   • Publish Year: 2021

4. www.nature.com › articles › nature12879Patterning and growth control by membrane-tethered Wingless

   www.nature.com › articles › nature12879

   Dec 25, 2013 · Replacement of the wingless (wg) gene in Drosophila with one that expresses a membrane-tethered form of Wg results in viable flies with normally patterned appendages of nearly the right size ...

   • Author: Cyrille Alexandre, Alberto Baena-Lopez, Jean-Paul Vincent

   • Publish Year: 2014

5. link.springer.com › article › 10The color pattern inducing gene wingless is expressed in ...

   link.springer.com › article › 10

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   Mar 27, 2021 · A polka-dotted fruit fly, Drosophila guttifera, has a unique pigmentation pattern on its wings and is used as a model for evo-devo studies exploring the mechanism of evolutionary gain of novel traits. In this species, a morphogen-encoding gene, wingless, is expressed in species-specific positions and induces a unique pigmentation pattern.

   • Author: Masato Koseki, Nobuaki K Tanaka, Shigeyuki Koshikawa

   • Publish Year: 2021

6. www.nature.com › articles › s41467/022/32400-2A single WNT enhancer drives specification and regeneration ...

   www.nature.com › articles › s41467/022/32400-2

   Aug 22, 2022 · The fly wing primordium has served as a useful model system to visualise how Wg acts as fate determinant and mitogenic molecule in two consecutive developmental time points.

7. www.science.org › doi › 10How the Fruit Fly Got His Spots | Science Signaling - AAAS

   www.science.org › doi › 10

   Apr 27, 2010 · When expressed in D. melanogaster, which lacks spots, the D. guttifera vein spot CRE drove reporter expression in pupal wing in a pattern resembling that of endogenous wingless.

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   Do wingless flies produce patterned appendages?

   • Surprisingly, the resulting flies were viable and produced normally patterned appendages of nearly the right size, albeit with a delay. We show that, in the prospective wing, prolonged wingless transcription followed by memory of earlier signalling allows persistent expression of relevant target genes.

   Patterning and growth control by membrane-tethered Wingless

   www.nature.com/articles/nature12879

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   What is the wingless pathway?

   • Wingless, the fly homolog of the mammalian Wnt oncoproteins, plays a central role in pattern generation during development. Much of what we know about the pathway was learned from genetic and molecular experiments in Drosophila melanogaster, and the core pathway works the same way in vertebrates.

   Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis

   academic.oup.com/genetics/article/208/4/1311/6087235

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   What is wingless gene activity?

   • As the name suggests, wingless (wg) gene activity is required for generating the pattern of the adult fly wing, among its many functions during Drosophila development.

   Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis

   academic.oup.com/genetics/article/208/4/1311/6087235

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   What is wingless in Drosophila?

   • The development of wingless, a homeotic mutation of Drosophila. Constitution of the germinal material in relation to heredity. Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes. Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility.

   Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis

   academic.oup.com/genetics/article/208/4/1311/6087235

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   Do NRT-WG flies make a perfectly patterned wing margin?

   • This confirms our suggestion that a minor extension of the growth period helps NRT–Wg flies to make a perfectly patterned wing margin. Our evidence so far is consistent with the notion that the developmental delay of wg { KO; NRT–Wg } animals could be due mostly to a mild reduction in expression and hence activity.

   Patterning and growth control by membrane-tethered Wingless

   www.nature.com/articles/nature12879

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   What is fly wing development?

   • Fly wing development is a well-studied developmental system where several important cell signals have been characterized. Amongst these is the secreted cell-signalling protein DWnt1/Wingless (Wg), which has sequential expression patterns and functions in wing development 12, 13, culminating in the patterning of the presumptive wing margin.

   Pegasus, a small extracellular peptide enhancing short-range ... - Nature

   www.nature.com/articles/s41467-021-25785-z

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9. www.biorxiv.org › content › 10The color pattern inducing gene wingless is expressed in ...

   www.biorxiv.org › content › 10

   20 A polka-dotted fruit fly, Drosophila guttifera, has a unique pigmentation pattern on its wings 21 and is used as a model for evo-devo studies exploring the mechanism of evolutionary gain of 22 novel traits.