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Sep 2, 2014 · William R. Jacobs, Jr. Photo courtesy of Paras Jain. Since the mid-1980s, Jacobs has used phages to develop gene-transfer systems for Mycobacterium tuberculosis that have allowed researchers to identify tuberculosis (TB) drug targets and their mechanisms of action, study the virulence mechanisms of M. tuberculosis , and distinguish drug-sensitive from extensively drug-resistant strains.
902. 1999. Mechanisms of drug resistance in Mycobacterium tuberculosis. Y Zhang, WR Jacobs Jr, C Vilchèze. Tuberculosis and the tubercle bacillus, 115-140. , 2005. 900. 2005. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.
Tiwari S, Casey R, Goulding CW, Hingley-Wilson S, Jacobs WR Jr. (2019) Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1. Microbiol Spectr. PMID: 31172908; Porcelli, S.S, Jacobs WR Jr. (2019). Eacting Edward Jenner's Revenge: The quest for a new tuberculosis vaccine.
Sep 9, 2014 · William R. Jacobs, Jr. Photo courtesy of Paras Jain. Since the mid-1980s, Jacobs has used phages to develop gene-transfer systems for Mycobacterium tuberculosis that have allowed researchers to identify tuberculosis (TB) drug targets and their mechanisms of action, study the virulence mechanisms of M. tuberculosis , and distinguish drug-sensitive from extensively drug-resistant strains.
- Ann Griswold
- 10.1073/pnas.1407879111
- 2014
- 2014/09/09
Profile of William R. Jacobs, Jr. The expression on the young man’s face as he stood by the railing surrounding the zebra enclosure at the Bronx Zoo might have been mistaken for awe at the animalsmagnificent ’ hides or spry gaits. However, as the man reached into the enclosure and scooped a clump of soil and zebra dung into his hands, he ...
William R. Jacobs Jr., is a professor of Microbiology and Immunology and Professor of Genetics at Albert Einstein College of Medicine in The Bronx, New York, where he is also a Howard Hughes Medical Institute Investigator. Jacobs is a specialist in the molecular genetics of Mycobacteria. [1] His research efforts are aimed at discovering genes ...
The Scientist - April 08, 2019. William Jacobs Jr., Ph.D., talks about the development of tuberculosis infections in humans on immune-boosting cancer treatments. Dr. Jacobs is professor of microbiology & immunology and of genetics and the Leo and Julia Forchheimer Chair in Microbiology & Immunology at Einstein.
