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- Chronic brain inflammation is linked to depression and other cognitive and mental health problems. Specific anti-inflammatory lifestyle changes can help. Inflammation is the body’s first line of defense against infection and injury. This process normally shuts down after healing is complete.
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Coordinated in part by the brain’s resident immune cells—microglia and astrocytes—neuroinflammation ordinarily protects against infection and injury.
Nov 24, 2021 · Our immune system and brain interact on multiple scales, but how the brain represents and remembers immune challenges remains unclear. In this issue of Cell, Koren et al. (2021) reveal that the brain’s insular cortex stores information about inflammation in the body.
- Nadine Gogolla
- 2021
Neuroinflammation is defined as an inflammatory response within the brain or spinal cord. This inflammation is mediated by the production of cytokines, chemokines, reactive oxygen species, and secondary messengers. These mediators are produced by resident CNS glia (microglia and astrocytes), endothelial cells, and peripherally derived immune cells.
May 14, 2024 · Infections can activate neural circuits that mediate responses such as fever and malaise. Jin et al. describe a body-to-brain neural circuit that informs the brain of emerging inflammatory...
- Alexandra Flemming
- a.flemming@nature.com
Jul 1, 2019 · After an acute neurological incident, whether traumatic or non-traumatic, markers of inflammation increase in the brain and systemically within minutes; a cascade of immune events follows.
- Nils Erik Gilhus, Günther Deuschl
- 2019
Jun 12, 2023 · The activation of glial cells and complement-mediated pathways, the synthesis of inflammation mediators, and the recruitment of leukocytes, are key elements of brain inflammation.
Jan 10, 2022 · The effects of increased systemic inflammation on vascular brain health are beginning to translate from conceptual approaches for targeting inflammation as a therapeutic strategy into clinical trials and practice.