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Proliferation and synaptogenesis, neural plasticity, and regeneration
- One or more GAG chains are usually found in nature bound to polypeptide backbones in the form of proteoglycans; HA is the exception. In the nervous system, GAG/proteoglycan-mediated interactions participate in proliferation and synaptogenesis, neural plasticity, and regeneration.
pubmed.ncbi.nlm.nih.gov/36255674/Chemistry and Function of Glycosaminoglycans in the Nervous ...
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Feb 19, 2015 · Glycosaminoglycans (GAGs) are major components of the ECM and exist as a diverse array of differentially sulphated disaccharide units. In the central nervous system (CNS), they are expressed by both neurons and glia and are crucial for brain development and brain homeostasis.
- Dáire Rowlands, Kazuyuki Sugahara, Jessica C F Kwok
- 2015
Complex changes in proteoglycans and associated GAG-chains have been described in areas where neural stem cells reside during brain development, suggesting that proteoglycans could regulate neural stem cell survival, proliferation, and /or differentiation (Akita et al. 2008; Sirko et al. 2010a).
Sep 11, 2019 · A recent study in aged mice has found that Bral2, a link protein that stabilizes HA and CSPG interactions in the brain, is reduced in aged mice with resulting disruption of PNNs. 70 PNN function also depends on the GAG chains of CSPGs. It is generally accepted that C4 sulfation of GAGs is inhibitory at the same time C6 sulfation promotes neural ...
- May J Reed, Mamatha Damodarasamy, William A Banks
- 10.1080/21688370.2019.1651157
- 2019
- Tissue Barriers. 2019; 7(4): 1651157.
Proteoglycans (PGs) are a diverse family of proteins that consist of one or more glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major components of the extracellular matrix (ECM) and play critical roles in development, normal function and damage-response of the central ….
- Patrice D. Smith, Patrice D. Smith, Vivien J. Coulson-Thomas, Simona Foscarin, Jessica C.F. Kwok, Ja...
- 2015
Jan 12, 2022 · Brain glycans correlate with RNA expression of their synthetic enzymes, and analysis of glycosylation genes in humans show a global downregulation in the brain compared to other tissues.
In the nervous sys-tem, GAG/proteoglycan-mediated interactions participate in proliferation and syn-aptogenesis, neural plasticity, and regeneration. This review focuses on the structure, chemistry and function of GAGs in nervous system development, disease, function and injury response.
Proteoglycans are diverse, complex extracellular/cell surface macromolecules composed of a central core protein with covalently linked glycosaminoglycan (GAG) chains; both of these components contribute to the growing list of important bio-active functions attributed to proteoglycans.
