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Proliferation and synaptogenesis, neural plasticity, and regeneration
- One or more GAG chains are usually found in nature bound to polypeptide backbones in the form of proteoglycans; HA is the exception. In the nervous system, GAG/proteoglycan-mediated interactions participate in proliferation and synaptogenesis, neural plasticity, and regeneration.
pubmed.ncbi.nlm.nih.gov/36255674/Chemistry and Function of Glycosaminoglycans in the Nervous ...
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One or more GAG chains are usually found in nature bound to polypeptide backbones in the form of proteoglycans; HA is the exception. In the nervous system, GAG/proteoglycan-mediated interactions participate in proliferation and synaptogenesis, neural plasticity, and regeneration.
Feb 19, 2015 · Glycosaminoglycans (GAGs) are major components of the ECM and exist as a diverse array of differentially sulphated disaccharide units. In the central nervous system (CNS), they are expressed by both neurons and glia and are crucial for brain development and brain homeostasis.
- Dáire Rowlands, Kazuyuki Sugahara, Jessica C F Kwok
- 2015
Jan 1, 2014 · Complex changes in proteoglycans and associated GAG-chains have been described in the areas where neural stem cells reside during brain development, supporting the idea that proteoglycans could regulate neural stem cell survival, proliferation, and/or differentiation (Akita et al. 2008; Sirko et al. 2010a).
- Nancy B. Schwartz, Miriam S. Domowicz
- 2014
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a ...
GAGs are classified based on their disaccharide subunits, into the following major groups: chondroitin sulfate (CS), heparan sulfate (HS), heparin (HEP), dermatan sulfate (DS), keratan sulfate (KS) and hyaluronic acid (HA). All except HA are modified by sulfation, giving GAG chains specific charged structures and binding properties.
- Patrice D. Smith, Patrice D. Smith, Vivien J. Coulson-Thomas, Simona Foscarin, Jessica C.F. Kwok, Ja...
- 2015
In the nervous system, GAG/proteoglycan-mediated interactions participate in proliferation and synaptogenesis, neural plasticity, and regeneration. This review focuses on the structure, chemistry and function of GAGs in nervous system development, disease, function and injury response.
Glycosaminoglycans (GAGs) are a family of linear, highly negatively charged polydisperse polysaccharides, some variably sulfated but others not, and expressed ubiquitously and abundantly on the cell surface and in the extracellular matrix. GAGs are also found in invertebrates and prokaryotes.
