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Oct 28, 2021 · While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that DNA mismatch repair (MMR) impedes prime editing and promotes undesired indel byproducts.
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Cell. 2021 Oct 28;184 (22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018.
Oct 21, 2021 · Chen et al. (2021) have identified many internal ribosome entry site-like elements that can potentially drive circRNA translation. Dozens of such element-containing circRNAs-encoded peptides are validated, among which a circFGFR1-encoded protein acts as an antagonist of FGFR1.
Nov 1, 2021 · Gallic acid (GA) is a naturally occurring phenolic acid compound. •. GA stimulates apoptosis in tumor cells and suppresses their migration. •. GA enhances sensitivity of tumor cells to chemotherapy.
Sep 11, 2023 · Title: 骊歌行 / Li Ge Xing. English title: Court Lady. Also known as: 大唐儿女行 / Da Tang Er Nu Xing. Genre: Historical, romance. Episodes: 55. Broadcast network: iQiyi, Tencent. Broadcast period: 2021-Apr-15. Original soundtrack: Court Lady OST.
With the rapid development of NIR pc-LEDs, the development of a novel NIR phosphor with broadband emission, strong luminescence and high thermal stability is urgent. Here, three isotypic garnet fluorides Na 3 X 2 Li 3 F 12 (X = Al, Ga, or In) (NXLF) activated by Cr 3+ were synthesized.
Jun 25, 2021 · Deng C, Chen S, Chen D, He Y, Wu Q. Sketch, ground, and refine: Top-down dense video captioning. 2021. Paper presented at IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2021.
