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Oct 28, 2021 · While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that DNA mismatch repair (MMR) impedes prime editing and promotes undesired indel byproducts.
- Peter J. Chen, Peter J. Chen, Peter J. Chen, Jeffrey A. Hussmann, Jun Yan, Friederike Knipping, Purn...
- 2021
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Cell. 2021 Oct 28;184 (22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018.
Oct 21, 2021 · Chen et al. (2021) have identified many internal ribosome entry site-like elements that can potentially drive circRNA translation. Dozens of such element-containing circRNAs-encoded peptides are validated, among which a circFGFR1-encoded protein acts as an antagonist of FGFR1.
- Chu-Xiao Liu, Ling-Ling Chen, Ling-Ling Chen
- 2021
Nov 1, 2021 · Gallic acid (GA) is a naturally occurring phenolic acid compound. •. GA stimulates apoptosis in tumor cells and suppresses their migration. •. GA enhances sensitivity of tumor cells to chemotherapy.
- Milad Ashrafizadeh, Ali Zarrabi, Sepideh Mirzaei, Farid Hashemi, Saeed Samarghandian, Amirhossein Za...
- 2021
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Title:骊歌行 / Li Ge XingEnglish title:Court LadyAlso known as:大唐儿女行 / Da Tang Er Nu XingGenre:Historical, romanceSheng Chu Mu, son of one of the founding marshals of the Tang Dynasty, was a playful and wayward man, but his life took a radical turn when fell in love at first sight with Fu Rou, the diligent daughter of a merchant family. In order to woo Fu Rou's heart, Chu Mu began to study earnestly. As Sheng Chu Mu grow in knowledge and maturity, he decided t...
Original Writing: Lao Hu Bu Xia Shin (老虎不下山) by Feng NongDirector: Wang Xiao Ming, Bai Yun Mo, Kun Zhao Qing(申兆清)Screenwriter: Feng NongProducer: Yu Zheng, Yang Le, Fang FangWith the rapid development of NIR pc-LEDs, the development of a novel NIR phosphor with broadband emission, strong luminescence and high thermal stability is urgent. Here, three isotypic garnet fluorides Na 3 X 2 Li 3 F 12 (X = Al, Ga, or In) (NXLF) activated by Cr 3+ were synthesized.
Jun 25, 2021 · Deng C, Chen S, Chen D, He Y, Wu Q. Sketch, ground, and refine: Top-down dense video captioning. 2021. Paper presented at IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2021.
