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Dr. Dr. med. Sergio Castro-Gomez (MD-PhD) Clinic for Neurodegenerative Diseases - Gerontopsychiatry. Sergio Castro-Gomez studied medicine at the Universities of Antioquia (Medellín – Colombia) and Hamburg and received his MD-PhD at the University of Hamburg.
Jul 25, 2024 · Both α-syn and tau aggregates exhibit “prion-like” characteristics, spreading from cell to cell and inducing the misfolding of native proteins in neighboring neurons, thereby propagating neuronal damage and neurodegeneration across interconnected brain regions.
Feb 24, 2023 · In this review, the established procedures and future directions in the diagnostics of ALS are summarized to serve as a practical guideline and to improve the diagnostic pathway of this burdensome disease. Keywords: ALS; MND; amyotrophic lateral sclerosis; diagnosis; diagnostics; motor neuron disease.
Nov 16, 2022 · The clinical examination revealed a motor neuron syndrome with a clear bilateral wasting of the hand muscles, a diffuse atrophy of the shoulder and calf muscles, and a weakness of the arms, fingers, hips, and feet. Deep tendon reflexes were symmetrically briskly hyperactive.
Dec 31, 2023 · Serum cardiac Troponin T (cTnT), widely in use as a serum marker of myocardial injury, has recently emerged as a promising candidate serum biomarker for ALS, correlating with disease severity and progression6,7. Accumulating evidence suggests that degenerating or regenerating skeletal muscle is an.
In brief. Scheiblich et al. uncover a novel mechanism by which microglia use tunneling nanotubes to connect with -syn- or tau-burdened neurons, a. enabling transfer of these proteins to microglia for clearance. Microglia donate mitochondria to restore neuronal health, shedding light on new therapeutic strategies for neurodegenerative diseases.
Sergio Castro-Gomez studied medicine at the Universities of Antioquia (Medellín Colombia) and Hamburg, and received his – MD-PhD in 2016 at the University of Hamburg.
