Search results
SUMMARY. Microglia are crucial for maintaining brain health and neuron function. Here, we report that microglia establish connections with neurons using tunneling nanotubes (TNTs) in both physiological and patho-logical conditions. These TNTs facilitate the rapid exchange of organelles, vesicles, and proteins.
Jul 25, 2024 · In neurodegenerative diseases like Parkinson’s and Alzheimer’s disease, toxic aggregates of alpha-synuclein (α-syn) and tau accumulate within neurons. Our research demonstrates that microglia use TNTs to extract neurons from these aggregates, restoring neuronal health.
Nov 16, 2022 · The clinical examination revealed a motor neuron syndrome with a clear bilateral wasting of the hand muscles, a diffuse atrophy of the shoulder and calf muscles, and a weakness of the arms, fingers, hips, and feet. Deep tendon reflexes were symmetrically briskly hyperactive.
Dr. Dr. med. Sergio Castro-Gomez (MD-PhD) Clinic for Neurodegenerative Diseases - Gerontopsychiatry. Sergio Castro-Gomez studied medicine at the Universities of Antioquia (Medellín – Colombia) and Hamburg and received his MD-PhD at the University of Hamburg.
Jan 6, 2022 · Sergio Castro-Gomez Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of upper and lower motor neurons, resulting in progressive weakness of all ...
Sep 25, 2024 · In neurodegenerative diseases like Parkinson's and Alzheimer's disease, toxic aggregates of alpha-synuclein (α-syn) and tau accumulate within neurons. Our research demonstrates that microglia use TNTs to extract neurons from these aggregates, restoring neuronal health.
Apr 9, 2024 · We describe common key immune activation pathways across NDDs, followed by a summary of the latest findings regarding receptors recognizing DAMPs in Alzheimer’s disease (AD) as the most studied NDD, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD).
