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- Translation initiation starts with the binding of eukaryotic translation initiation factor 1 (eIF1), eIF1A and eIF3 to the 40S small ribosomal subunit (top left and clockwise). eIF5 and a ternary complex of eIF2, guanosine 5′-triphosphate (GTP) and the methionine initiatior tRNA (Met-tRNA iMet) binds to this complex to form a 43S translation pre-initiation complex (43S).
www.nature.com/articles/s41580-023-00624-9
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Key Points. Translation is a cyclical process in which ribosomal subunits that participate in initiation are derived by recycling of post-termination ribosomal complexes (post-TCs) that have...
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Jul 8, 2022 · Protein synthesis in eukaryotes is carried out by 80S ribosomes with the help of many specific translation factors. Translation comprises four major steps: initiation, elongation, termination, and ribosome recycling.
- Sandra Blanchet, Namit Ranjan
- 2022/07/08
- 10.1007/978-1-0716-2501-9_13
Dec 5, 2023 · Eukaryotic translation initiation factor 2 (eIF2) is the initiation factor that delivers the Met-tRNA i Met to the P site, and one of the main targets for translation regulation.
Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.
The initiation of protein synthesis consists in the recruitment of a ribosome·initiator tRNA complex to the initiation codon of a messenger RNA. In prokaryotes, this process involves the direct interaction of the ribosomal RNA with the mRNA.
- Francis Poulin, Nahum Sonenberg
- 2013
- 2013
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. Mol Cell 26: 41–50 [Google Scholar] Paulin FE, Campbell LE, O’Brien K, Loughlin J, Proud CG 2001. Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein.
Jun 5, 2012 · Translation initiation in eukaryotes is a complex and highly regulated process requiring the action of at least 12 protein factors. The pathway is distinguished by the formation of a...
