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Azithromycin
- Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-sensing and reduces the formation of biofilm.
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Oct 6, 2020 · Vancomycin is a lipophilic cationic antibiotic that inhibits synthesis of the bacterial cell wall by binding to the dipeptide terminus d-Ala-d-Ala of peptidoglycan pentapeptide precursors ...
- Nature
We would like to show you a description here but the site...
- Structural and mechanistic basis for translation inhibition ...
Macrolides and ketolides comprise a family of clinically...
- Target protection as a key antibiotic resistance mechanism
The antibiotic fusidic acid inhibits bacterial protein...
- Nature
Jul 22, 2021 · Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome.
- Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michae...
- 2021
Jun 25, 2020 · The antibiotic fusidic acid inhibits bacterial protein synthesis by binding to EF-G on the ribosome and preventing disassembly of the post-translocation complex; the resultant steric...
- Daniel N. Wilson, Vasili Hauryliuk, Vasili Hauryliuk, Gemma C. Atkinson, Alex J. O’Neill
- 2020
Aug 23, 2022 · Most inhibitors of protein synthesis are bacteriostatic, so proper protein synthesis can resume once the antibiotic is removed. Thus the effect of these antibiotics is to prevent the growth of the bacteria. However, aminoglycosides, which are also inhibitors of protein synthesis, are bactericidal.
Sep 1, 2016 · Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial ribosomes and the translational machinery represent one of the major targets for antibiotics in the cell.
- Stefan Arenz, Daniel N. Wilson
- 2016
Azithromycin. Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly phagocytes, it is delivered in high concentrations to sites of infection, as reflected in rapid plasma clearance and ….
This review summa-rizes the recent advances in our understanding of protein synthesis, particularly with respect to X-ray and cryoelectron microscopy (cryo-EM) structures of ribosome complexes, and highlights the different steps of translation that are targeted by the diverse array of known antibiotics.
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