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Dementia in Down’s syndrome Clive Ballard, William Mobley, John Hardy, Gareth Williams, Anne Corbett Down’s syndrome is the most common genetic cause of learning diffi culties, and individuals with this condition represent the largest group of people with dementia under the age of 50 years. Genetic drivers result in a high
- A Cross-Sectional Study
Studies have assessed Alzheimer's disease in individuals...
- A Cross-Sectional Study
Summary Down's syndrome is the most common genetic cause of learning difficulties, and individuals with this condition represent the largest group of people with dementia under the age of 50 years.
Jun 27, 2020 · Studies have assessed Alzheimer's disease in individuals with Down syndrome, but the natural history of biomarker changes in Down syndrome has not been established. We characterised the order and timing of changes in biomarkers of Alzheimer's disease in a population of adults with Down syndrome.
- Juan Fortea, Eduard Vilaplana, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Isabel Barroeta, S...
- 2020
Feb 7, 2019 · Ballard and colleagues developed a hypothetical model of different biomarker and clinical outcomes reflecting the progression of Alzheimer disease in Down syndrome.
- Ira T. Lott, Elizabeth Head
- 2019
May 1, 2016 · We first briefly describe the epidemiological and clinical characteristics of dementia in Down's syndrome, and then focus on the most recent developments in the neurobiology of dementia in this population, including imaging and pathophysiological changes and genetic risk factors.
- Clive Ballard, William Mobley, John Hardy, Gareth Williams, Anne Corbett
- 2016
Mar 13, 2017 · Adults with Down syndrome (DS) are at a very high risk of developing early onset Alzheimer’s disease (AD) due to trisomy of chromosome 21. AD is preceded by a prolonged prodromal “pre-clinical” phase presenting with clinical features that do not fulfil the diagnostic criteria for AD.
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Down's syndrome is the most common genetic cause of learning difficulties, and individuals with this condition represent the largest group of people with dementia under the age of 50 years.
