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1. www.nature.com › articles › s41375/019/0413-0Standardisation and consensus guidelines for minimal residual ...

   www.nature.com › articles › s41375/019/0413-0

   Mar 11, 2019 · Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase...

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2. www.nature.com › articles › s41375/022/01612-2Impact of BCR::ABL1 transcript type on RT-qPCR ... - Nature

   www.nature.com › articles › s41375/022/01612-2

   Jun 8, 2022 · Branford S, Hughes TP, Rudzki Z. Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics.

   • Author: Matthew Salmon

3. www.annalsofoncology.org › article › S0923-7534(19Quantitative measurement of BCR/abl transcripts usingreal ...

   www.annalsofoncology.org › article › S0923-7534(19

   May 2, 2001 · Quantitative real-time polymerase chain reaction (Q-Rt-PCR) is a new tool in the detection and quantification of the BCR/abl fusion transcripts in chronic myelogenous leukemia (CML). This study investigates its specificity, sensitivity and potential clinical usefulness.

   • Author: W. I. Lee, Hagop M Kantarjian, A. Glassman, M. Talpaz, M. S. Lee

   • Publish Year: 2002

4. ashpublications.org › blood › articleApplication of Real-Time PCR for the Detection of BCR-ABL1 ...

   ashpublications.org › blood › article

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   Nov 29, 2018 · To find out whether expression profile based on combined expression data of 5 genes assessed by real-time PCR can be used for the identification of BCR-ABL1 -like pediatric ALL patients. Methods. The study was done on initial bone marrow samples of 147 primary pediatric BCP-ALL patients.

   • Author: Grigory Tsaur, Tatiana Muhacheva, Sergey Kovalev, Alexander Druy, Petr Sibiryakov, Yulia Olshanskaya...

   • Publish Year: 2018

5. www.ncbi.nlm.nih.gov › pmc › articlesDigital PCR for BCR-ABL1 Quantification in CML: Current ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · Real-time quantitative PCR (qPCR) is the routinely used method, but has limitations in quantification accuracy due to its inherent technical variation. Treatment recommendations rely on specific BCR-ABL1 values set at timed response milestones, making precise measurement of BCR-ABL1 a requisite.

   • Author: Camille C B Kockerols, Peter J M Valk, Mark-David Levin, Niels Pallisgaard, Jan J Cornelissen, Peter...
   • DOI: 10.1097/HS9.0000000000000496

   • Publish Year: 2020
   • Publication: Hemasphere. 2020 Dec; 4(6): e496.

6. pubmed.ncbi.nlm.nih.gov › 29675955Rapid identification of BCR/ABL1-like acute lymphoblastic ...

   pubmed.ncbi.nlm.nih.gov › 29675955

   We propose a simple tool based on Q-RT-PCR and a statistical model that is capable of easily, quickly and reliably identifying BCR/ABL1-like ALL cases at diagnosis. Keywords: Acute lymphoblastic leukaemia; BCR/ABL1-like; adults; prognosis; tyrosine kinase inhibitors.

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   Can quantitative real-time PCR detect bcr/abl fusion transcripts?

   • It provides not only detection but also quantification of the accumulated target PCR products. To validate quantitative real-time PCR (Q-Rt-PCR) in the detection of BCR/abl fusion transcripts, we performed side-by-side comparison analysis with conventional reverse transcription-mediated PCR (RT–PCR).

   Quantitative measurement of BCR/abl transcripts usingreal-time

   www.annalsofoncology.org/article/S0923-7534(19)62895-4/fulltext

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   How is BCR ABL1 transcript type determined?

   • The BCR::ABL1 transcript type expressed by individual patients is determined largely by the precise positions of the genomic breakpoints on chromosomes 22 and 9 , and is thus stable over time.

   Impact of BCR::ABL1 transcript type on RT-qPCR amplification performa…

   www.nature.com/articles/s41375-022-01612-2

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   What is a standard curve for ABL1?

   • The corresponding standard curve typically generated a mean slope of −3.45 and an intercept of 41.57 for pME-3 (calculated from QC3, 4, 5, 6). A mean CT value of 27 was generated for 10 000 copies of ABL1 with a threshold set at 0.1.

   Standardisation and consensus guidelines for minimal residual disease a…

   www.nature.com/articles/s41375-019-0413-0

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   What is the ratio of BCR-ABL1 and ABL1?

   • The ratio is defined as the ratio between the copy numbers of BCR-ABL1 and ABL1 plotted on the y-axis (log-transformed). The median corresponds to the horizontal line, the box refers to the range defined by the 25 th and 75 th percentiles, the whiskers refer to the range defined by the 10–90 percentiles.

   Standardisation and consensus guidelines for minimal residual disease a…

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   What percentage of Qc1 analyses have bcr-abl1/abl1 ratios within half a log difference?

   • In QC1 the proportion of analyses with BCR-ABL1/ABL1 ratios within half a log difference were 40/67 (60%) and 52/67 (78%) at 10 −3 and 36/67 (53%) and 53/67 (79%) at 10 −4BCR-ABL1/ABL1.

   Standardisation and consensus guidelines for minimal residual disease a…

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8. pmc.ncbi.nlm.nih.gov › articles › PMC7694607Standardization of BCR-ABL1 p210 Monitoring: From Nested to ...

   pmc.ncbi.nlm.nih.gov › articles › PMC7694607

   The diagnostic and clinical success of standardization of BCR-ABL1 p210 monitoring in chronic myeloid leukemia patients could be seen as a good example for further standardization of molecular monitoring in other gene rearrangements.