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Phenethylamine [note 1] (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amine-associated receptor 1 (TAAR1) and inhibiting vesicular monoamine transporter 2 (VMAT2) in ...
Aug 22, 2024 · The human body synthesizes PEA through a process called decarboxylation of the amino acid phenylalanine. This biosynthesis primarily occurs in the brain, where PEA can exert its effects directly on neural circuits.
Sep 30, 2024 · First and foremost, the study of pea-sized brains is being revolutionized by advances in technology. New imaging techniques, such as micro-CT scans and electron microscopy, are allowing scientists to peer into these tiny organs with unprecedented detail.
May 5, 2022 · PEA belonging to the N-acetylanolamine class of phospholipids was first isolated from soy lecithin, egg yolk, and peanut flour. It is currently used for the treatment of different types of neuropathic pain, such as fibromyalgia, osteoarthritis, carpal tunnel syndrome, and many other conditions.
- 10.3390/biom12050667
- 2022/05
- Biomolecules. 2022 May; 12(5): 667.
Dec 16, 2019 · The human brain forms PEA from the essential amino acid l-phenylalanine by an enzyme-driven cellular process. Phenylalanine is the precursor to the amino acid tyrosine, which produces the neurotransmitters dopamine, norepinephrine, and adrenalin in a sequential process, but phenylalanine supplements don’t significantly boost PEA concentrations.
PEA has also been found in the brains of humans and other mammals (Paterson et al., 1990; Philips et al., 1978), which is facilitated by its high solubility in plasma and its ability to cross the blood-brain barrier (Oldendorf, 1971).
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Aug 19, 2016 · The first mechanism of action for PEA was proposed by Rita Levi-Montalcini's research group, who suggested that PEA acts via ‘Autacoid Local Injury Antagonism (ALIA)’ to down-regulate mast cell activation (Aloe et al., 1993; Levi-Montalcini et al., 1996).
