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Key points. Randomised studies of PEP have not been done, but experience suggests it is effective in preventing HIV infection. PEP is most effective when it is started soon after exposure to HIV, when doses are not missed and when people complete the 28-day course. The most common cause of HIV infection in people who take PEP is ongoing risk ...
- What Is Pep?
- Does Pep Work?
- How Does Pep Work?
- How Well Does Pep Work?
- How Soon After Sex Do You Need to Take Pep?
- How Many Drugs Are in Pep?
- Which Drugs Are Used For Pep?
- Can Efavirenz Be Used in Pep?
- What If The HIV Is Resistant to The Pep Drugs?
- How Long Do You Need to Take Pep for?
PEP is a way to use HIV meds AFTER sex to try to prevent HIV infection. This usually involves taking a combination of three daily oral meds for 28 days. Sometimes two or three of these meds will be in a single pill. Any 3-drug ART combination can be used as PEP so long as it does not contain abacavir or an NNRTI. This can include drugs that are not...
Yes, PEP can stop HIV infection. It also reduces the risk of HIV. Starting as soon as possible gives PEP the best chance to work. PEP is most effective if taken within 24 hours. PEP can only work though if you take it, especially for the first week. If you miss doses this could reduce the chance it will work, Current guidelines recommend taking the...
HIV takes a little time for HIV infection to become established. This might be anything from a few hours to a few days. This leaves a short window for PEP to work in two ways. 1. PEP might stop HIV infecting any cells at all. 2. It might also stop HIV from spreading beyond the first infected cells. Having good levels of HIV drugs at the right time ...
PEP is very effective. If you are taking PEP, it is highly likely to work and be effective. This is the main thing to remember :) Defining how well PEP works is more difficult, but also will never be clearly known. This is because it is a very difficult thing to study. Firstly, HIV is not a very infectious virus. Even after higher-risk sex, this ch...
The sooner you take PEP, the sooner it can work. 1. Start as soon as possible. 2. This should ideally be within a few hours, or at least on the same day. 3. In practice it usually takes 24 hours to start. 4. The earlier it is started the earlier it can start to work. 5. PEP will not work after 72 hours (3 days).
PEP uses three drugs. 1. Sometimes all three drugs are in one daily pill. 2. Sometimes PEP involves taking several pills every day. 3. Only using two drugs will not be as effective as three. Sometimes though, if you only have two drugs, it is better than none. What if I was only given 2-drug PEP? PEP can be effective as a 2-drug combination. Recomm...
In the UK, PEP currently uses tenofovir/emtricitabine + raltegravir. 1. These meds need to be taken once a day, at roughly the same time every day for 28 days. 2. This combination can be taken with or without food. Different drugs are used in different countries. High income countries often use Biktarvy. This contains tenofovir/emtricitabine/bicteg...
In the UK, combinations that include efavirenzshould NOT be used as PrEP. This is because side effects of efavirenz include mood changes like anxiety and depression. There is also a very low risk of serious liver toxicity. To reduce side effects, efavirenz needs to be taken before bedtime and not within two hours of a high fat meal. These combinati...
If the HIV is resistant to one of the PEP drugs, PEP is still likely to work. This is because the other drug(s) will still be active. If the HIV is resistant to all three PEP drugs, then PEP will not work. However, this is very rare, even in countries where drug resistance is more common.
Oral PEP needs to be taken every day for 28 days. 1. It is best to take PEP meds together at roughly the same time each day. 2. PEP can be taken with or without food. 3. Sometimes PEP comes in a box of 30 doses. It does not matter whether or not you take these extra few days. 4. Do not take PEP for longer than 30 days. Taking PEP for longer doesn’t...
PEP must be started within 72 hours of coming into contact with the virus for it to be effective. It's only recommended following higher risk exposure, particularly where the sexual partner is known to be positive. PEP involves taking HIV treatment every day for 1 month. It may cause some side effects. You should be able to get PEP from:
- Know when to use PEP. You should consider getting PEP to stop HIV as soon as possible if you have: Had a condom break during anal sex. Had anal sex with no condom in particular if you’re were bottoming and your partner ejaculated in your arse, or.
- Know when NOT to use PEP. PEP is not recommended after oral sex or other low risk activities, such as kissing. If you’re not sure how risky it might have been, make sure you know the risk and talk to a healthcare professional or call the PEP hotline.
- Give yourself the best chance of PEP working. To be most effective, PEP should be started within a few hours of exposure to HIV. If it is not started within 72 hours (3 days) it is not likely to work.
- Understand the potential side effects of PEP. As with most antiretroviral drugs, PEP can cause side effects such as diarrhoea, headaches, nausea/vomiting and fatigue.
Jul 22, 2024 · PEP is most effective when initiated as soon as possible, ideally within 24 hours and no later than 72 hours after exposure. While a PEP regimen of two drugs can be effective, three drugs are preferred. It is recommended that people be given a 28-day prescription for PEP. This guideline includes recommended drug regimens for adults, adolescents ...
Aug 1, 2023 · Summary. Post-exposure prophylaxis for HIV must be initiated as soon as possible, ideally within 2 hours, and preferably within 24 hours of exposure. However, the period during which post-exposure prophylaxis (PEP) is most efficacious is often said to be within 72 hours of exposure. Most exposures have only a low risk of HIV transmission even ...
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Nov 9, 2023 · Post-exposure prophylaxis (PEP) to prevent HIV acquisition has been recommended for over three decades, but remains underutilised. Over the past decade, clinical trials have established the safety and tolerability of newer PEP regimens, particularly those containing integrase strand transfer inhibitors (INSTIs) combined with a tenofovir and lamivudine or emtricitabine backbone. Several of ...
