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1. ashpublications.org › thehematologist › articlePaul Ehrlich (1854-1915) and the Birth of Molecular Medicine

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   Oct 20, 2015 · Inspired by this atmosphere of great discoveries, Paul Ehrlich, born in Strehlen, German Kingdom of Prussia, near Breslau in 1854, became one of the most influential scientists of his time and a pioneer in the fields of hematology, immunology, chemotherapy, and pharmacology. 1-3 In his career, Ehrlich connected cellular and molecular theories ...

   • Author: Bernd Groner, Hans-Peter Horny, Fritz Sörgel, Udo Schumacher, Peter Valent

   • Publish Year: 2015

2. academic.oup.com › labmed › articlePathology—The Beginnings of Laboratory Medicine | Laboratory ...

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   Mar 6, 2021 · But of all the extraordinary laboratory testing advances, it was German physician Paul Ehrlich (1854–1915) who probably made the most substantial discoveries for the most laboratory areas—histology, hematology, immunology (for which he received the Nobel Prize), microbiology, and chemistry—by inventing a repository of stains.

   • Author: Angela Tomei Robinson

   • Publish Year: 2021

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4. www.tandfonline.com › doi › fullFull article: Paul Ehrlich, a prescient pioneer in the field ...

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   Jan 10, 2014 · The basis of unique chemoreceptors being used to develop more specific agents that not only target particular pathogens but also have no toxic host effect was proposed by Ehrlich. He realized that moving from laboratory studies to clinical implementation was fraught with dangers.

   • Author: Glenn S Tillotson, Stephen H Zinner

   • Publish Year: 2013

5. meridian.allenpress.com › 725 › 453067Paul Ehrlich | Archives of Pathology & Laboratory Medicine

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   Jun 1, 2001 · Ehrlich's techniques of fixation and staining of blood films with aniline dyes greatly facilitated the study of blood and bone marrow. Ehrlich distinguished 3 types of granulated white blood cells, as well as normoblasts, megaloblasts, and leukemic cells.

6. www.jstor.org › stable › 23334317Models for Biological Research: The Theory and Practice of ...

   www.jstor.org › stable › 23334317

   Ehrlich not only speculated on the behavior of synthetic chemicals toward his model of the protoplasm but also invoked biological specificity, a concept that would have a tremendous impact on immunology, drug development, and molecular biology. KEYWORDS - Paul Ehrlich; specificity; side chains; cellular structure; theory of immunity; chemotherapy.

7. www.nature.com › articles › nrd1498Paul Ehrlich: Magister Mundi | Nature Reviews Drug Discovery

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   Sep 1, 2004 · The very concept of chemotherapy, and his classification of cancer cells as 'feindliche Brüder' (hostile brothers), would suggest that Ehrlich's contributions to experimental cancer research were...

8. People also ask

   Why was Ehrlich a great chemist?

   • Ehrlich was convinced that many more drugs could be synthesized chemically and be directed specifically against microbes or even against cancer cells. However, in this phase of his career he also realized and studied certain limitations of therapy, such as drug resistance and toxicity.

   Paul Ehrlich (1854-1915) and His Contributions to the Foundation and

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   How did Paul Ehrlich contribute to hematology?

   • All in all, Paul Ehrlich demonstrated that blood cells are much more heterogeneous cells than had been assumed previously, thereby paving the way to a new era of research and to modern hematology. In 1882, Robert Koch presented the discovery of the causal agents of tuberculosis, the mycobacterium, to the Society for Physiology in Berlin.

   Paul Ehrlich (1854-1915) and His Contributions to the Foundation and

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   Why did Paul Ehrlich receive a Nobel Prize?

   • In 1908, Paul Ehrlich received the Nobel Prize in Physiology or Medicine together with Elie Metchnikoff for their work and basic insights into immunological defense mechanisms [ 7, 8, 9 ]. Both concepts were complementary and later formed the basis of humoral and cellular immunology.

   Paul Ehrlich (1854-1915) and His Contributions to the Foundation and

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   How did Paul Ehrlich contribute to microbiology?

   • Paul Ehrlich also contributed to the development of staining reactions through which other bacteria and microbes were detected and classified. For example, Ehrlich developed a precursor technique to the Gram staining of (Gram-positive) bacteria.

   Paul Ehrlich (1854-1915) and His Contributions to the Foundation and

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   What were Ehrlich's contributions to pharmacology?

   • He made seminal contributions to the development of an antiserum to combat diphtheria and to the approach to standardize methods related to the production of “therapeutic serum.” 9 Ehrlich also extended his ideas about distinct recognition-sites and binding (ligand-receptor) interactions.

   Paul Ehrlich (1854-1915) and the Birth of Molecular Medicine

   ashpublications.org/thehematologist/article/doi/10.1182/hem.V12.6.4513/462786/Paul-Ehrlich-1854-1915-and-the-Birth-of-Molecular

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   How did Ehrlich identify white blood cells?

   • Ehrlich's staining techniques enabled him to distinguish between the different types of white blood cell. He became the first scientist to characterize mast cells by their basophilic granules and to identify these cells as a structurally and functionally distinct type of cell.

   Paul Ehrlich: Magister Mundi - Nature Reviews Drug Discovery

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9. karger.com › jin › articlePaul Ehrlich (1854-1915) and His Contributions to the ...

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   Feb 5, 2016 · In the current article, we provide a short overview of Paul Ehrlich's life and career and a review of his major contributions to chemistry, hematology, immunology, pharmacology, drug development and translational medicine.