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  1. Results: Medication compliance and medication persistence are two different constructs. Medication compliance (synonym: adherence) refers to the degree or extent of conformity to the recommendations about day-to-day treatment by the provider with respect to the timing, dosage, and frequency. It may be defined as "the extent to which a patient ...

  2. Jan 1, 2008 · Medication compliance (synonym: adherence) refers to the degree or extent of conformity to the recommendations about day-to-day treatment by the provider with respect to the timing, dosage, and frequency. It may be defined as “the extent to which a patient acts in accordance with the prescribed interval, and dose of a dosing regimen.”.

    • Joyce A. Cramer, Anuja Roy, Anita Burrell, Carol J. Fairchild, Mahesh J. Fuldeore, Daniel A. Ollendo...
    • 2008
  3. Jun 25, 2007 · By definition, persistence is reported as a continuous variable in terms of number of days for which therapy was available. Persistence may also be reported as a dichotomous variable measured at the end of a predefined time period (e.g., 12 months), considering patients as being “persistent” or “nonpersistent.”

    • Joyce A. Cramer, Anuja Roy, Anita Burrell, Carol J. Fairchild, Mahesh J. Fuldeore, Daniel A. Ollendo...
    • 2008
  4. Medication compliance and medication persistence are two different constructs. Medication compliance (synonym: adherence) refers to the degree or extent of conformity to the recommendations about day-to-day treatment by the provider with respect to the timing, dosage, and frequency. It may be defined as "the extent to which a patient acts in ...

  5. First, the terms compliance and adherence are to be used synonymously and to be defined as, ”the extent to which a patient acts in accordance with the prescribed interval and dose of a dosing regimen”. Second, persistence should be defined as the, “the duration of time from initiation to discontinuation of therapy”.

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  6. or considered between refills; can include definition of time period allowed after last refill in the measurement period: Second stage persistence 6 Refill compliance Persistent/Persistence 31,38-43: Later-stage Non-persistence: Failure to have two or more refills over a time period consistent with current use of the drug. Can imply either that

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  8. So, although ‘compliance’ and ‘concordance’ are sometimes useful, I generally prefer the term ‘adherence’, which is being increasingly used. It comes from the Latin word adhaerere, which means to cling to, keep close, or remain constant. In the OED it is defined as ‘Persistence in a practice or tenet; steady observance or ...

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