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Learn about Heron Connect® support programs for patients and providers. Explore services, enrollment, and access solutions for CINVANTI® (aprepitant) injectable emulsion, SUSTOL® (granisetron) extended-release injection, and ZYNRELEF™ (bupivacaine and meloxicam) extended-release solution.
- Contraindications
- Warnings and Precautions
- Use in Specific Populations
- Adverse Reactions
CINVANTI is contraindicated in patients with hypersensitivity to any of the components of CINVANTI. Concurrent use of pimozide with CINVANTI is contraindicated.
Clinically Significant CYP3A4 Drug Interactions Aprepitant is a substrate, weak-to-moderate (dose-dependent) inhibitor, and an inducer of CYP3A4. 1. Use of CINVANTI with other drugs that are CYP3A4 substrates may result in increased plasma concentration of the concomitant drug. 1.1. Use of pimozide with CINVANTI is contraindicated due to the risk o...
Avoid use of CINVANTI in pregnant women as alcohol is an inactive ingredient for CINVANTI. There is no safe level of alcohol exposure in pregnancy.
The most common adverse reactions are: 1. Single-dose fosaprepitant with MEC (≥2%): fatigue, diarrhea, neutropenia, asthenia, anemia, peripheral neuropathy, leukopenia, dyspepsia, urinary tract infection, pain in extremity. 2. 3-day oral aprepitant with MEC (≥1% and greater than standard therapy): fatigue and eructation. 3. Single-dose fosaprepitan...
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