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Here, we summarize the main views of the different models of senescence, with a special emphasis on the biochemical processes that accompany aging. Though inherently complex, aging is characterized by numerous changes that take place at different levels of the biological hierarchy.
- João Pinto da Costa, Rui Vitorino, Gustavo M. Silva, Christine Vogel, Armando C. Duarte, Teresa Roch...
- 10.1016/j.arr.2016.06.005
- 2016
- 2016/08
5 days ago · Advantages and disadvantages The wear-and-tear theory on aging proposes that aging is a result of the accumulated damage to the body over time. The strongest evidence against the wear-and-tear theory is that bodies have a tremendous ability to repair damage. Scientists believe that aging is a result of complex biological processes that are not ...
Cellular Clock Theory: This theory suggests that biological aging is due to the fact that normal cells cannot divide indefinitely. This is known as the Hayflick limit, and is evidenced in cells studied in test tubes, which divide about 40-60 times before they stop (Bartlett, 2014).
- Martha Lally, Suzanne Valentine-French
- 2021
Jan 12, 2023 · By combining systematic review and concept analysis approaches in synthesizing theoretical models, this study comprehensively delineates and clarifies the concept of HA and its dimensions and explores whether a consensus is possible on a definition or model valid and applicable in multiple contexts.
- 10.1016/j.eclinm.2022.101821
- 2023/02
- eClinicalMedicine. 2023 Feb; 56: 101821.
Jun 2, 2016 · Abstract. The present article reviews theories of memory and aging over the past 50 years. Particularly notable is a progression from early single-mechanism perspectives to complex multifactorial models proposed to account for commonly observed age deficits in memory function.
- Denise C. Park, Sara B. Festini
- 2017
Jan 1, 2022 · Aging is an organism’s sequential or incremental transition that results in an increased risk of fatigue, illness, and death. Aging is multifaceted. Therefore, there are various hypotheses each of which may clarify one or more aspects of aging.
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Nearly all current theories of aging have in common the fact that the fundamental cause of aging is the accumulation of molecular damage brought about mainly by ROS, but the role of amyloid protein, glycation end-products, and lipofuscin is acknowledged as well.
