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May 4, 2023 · A different approach currently under investigation is a combination of the pan-PI3K inhibitor copanlisib with nivolumab in an ongoing phase I study that has now enrolled 14 patients with RT. 81 In this heavily pretreated patient population, the ORR was 29% (two CR and two PR). This study additionally includes patients with transformed follicular lymphoma, and across all 19 efficacy-evaluable ...
5 days ago · Haemopoietic (blood forming) stem cell transplants (HSCT) are one of the only successful therapies for Richter’s transformation, but they are rarely used. In this interview, Dr. Brian Koffman spoke with Dr. Adam Kittai, an associate professor of medicine at Mount Sinai. They discussed the role of haemopoietic stem cell transplants in treating ...
Jul 5, 2023 · Dr. Joel D. Richter, PhD, the Arthur F. Koskinas Chair in Neuroscience and professor of molecular medicine Fragile X syndrome is a genetic condition resulting from a CGG repeat expansion in the ...
Jan 9, 2024 · Purpose of Review This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter’s transformation (RT). Recent Findings Recently, numerous approaches have been investigated for the treatment of RT including: traditional chemoimmunotherapy regimens combined with targeted agents such as BTKi and BCL2i; immunotherapy combined with ...
Dec 9, 2023 · Chronic lymphocytic leukemia (CLL) is classified as an indolent B cell non-Hodgkin lymphoma according to the World Health Organization classification and is the most common type of leukemia in ...
- Othman Al-Sawaf
Dec 8, 2023 · Richter transformation (RT) represents an uncommon (2% to 10%) but feared complication of chronic lymphocytic leukemia (CLL). The disease is characterized by rapid disease kinetics, a high-risk genetic mutational profile, chemoimmunotherapy resistance, and consequent poor survival.
Oct 14, 2024 · When we’re thinking about that, the first step is meeting with your doctor who will do an exam and talk with you, and then we often get a PET scan when there’s concern for a transformation, because that can sometimes help us figure out where the area is that we should narrow in on and how we should go about getting a biopsy sample, because ...
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Is Richter transformation a complication of chronic lymphocytic leukemia (CLL)?
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How do you know if you have Richter transformation?
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Is CLL transformation to Richter syndrome convergent?
