Nature
Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion - Nature Communications
VAPB is a type IV transmembrane protein at the ER, and Iiis unknown how the VAPB MSP domain facing the cytosol is secreted. Here, the authors show that secretion of ER the protein VAPB requires topological inversion and Mmp1-mediated cleavage.
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