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- Host–guest interactions involve two molecules or materials that can form complexes through unique structural relationships and noncovalent binding. Also referred to as molecular recognition, this type of interaction is widely found in biorecognition processes, such as enzyme–inhibitor and antigen–antibody interactions.
www.sciencedirect.com/topics/chemistry/host-guest-interaction
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Are non-covalent host-guest interactions effective?
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How to prepare responsive materials using host–guest complexes?
How do we integrate therapeutic targeting with tumor microenvironment reprogramming?
Why do we heat and stir a host-guest complex?
Mar 9, 2017 · Non-covalent host–guest interactions are an effective tool to introduce switching and functional properties into materials. This review focuses on the achievement of selective molecular adhesion, self-healing, toughness, and actuation properties.
- Yoshinori Takashima, Akira Harada
- 2017
- Second-Order Induction–Polarization Energy
- London Dispersion
- Steric Repulsion (Pauli Exclusion) and Modeling of Van Der Waals Forces
- Charge Transfer
Ions and polar molecules create electric fields in the space surrounding them. This electric field can affect the distribution of a charge around any nearby molecules. Specifically, in response to an applied electric field the electrons in a molecular orbital will alter their distribution in a manner that mirrors the applied electric field. This in...
Above we have seen that a nearby charge (or even higher order moment, such as a dipole) will induce a counteracting dipole in any nearby polarizable electron cloud. It turns out, however, that even species lacking a charge (or even any higher moments) can induce the formation of a dipole in an effect now termed London dispersion after the physicist...
London dispersion and other induced-dipole interactions are the main attractive forces between molecules in the gas phase. They are thus responsible for an easily observable deviation that real gasses make from ideal gas behavior: whereas, the volume of an ideal gas is simply inversely proportional to the pressure, the volume of a real gas does not...
Interactions that we have discussed so far arise because of the electrostatic force between static or fluctuating charge distributions. By including induction, we allow these charge distributions to change within a molecule in response to charges around the molecule. But so far the electrons that create the charge distribution around the nuclei hav...
In order to inhibit the premature release, the host-guest interaction should tightly connect the building blocks to stabilize the supramolecular delivery systems. Triggered by the tumor-specific biomarkers, burst release is required upon endocytosis by the cancer cells arising from the dissociation of the host-guest complexation.
Feb 3, 2021 · To integrate therapeutic targeting with tumor microenvironment (TME) reprogramming, here we develop biocompatible, non-covalent channel-type nanoparticles (CNPs) that are fabricated through host...
- Hongzhen Bai, Jianwei Wang, Chi Uyen Phan, Qi Chen, Xiurong Hu, Guoqiang Shao, Jun Zhou, Lihua Lai, ...
- 2021
Jul 24, 2024 · Stimuli-responsive materials based on host -guest interactions, which possess specificity, efficiency, reversibility, and biocompatibility, represent a new category of platforms capable of making reversible transitions under stimuli. These materials exhibit outstanding capacity during the infection treatment process.
We use it to study a set of host-guest systems from the SAMPL5 challenge. We obtain highly accurate binding free energies and good agreement with experiments. The role of water during the binding process is then analysed in some detail.
Oct 24, 2024 · Supramolecular assemblies based on host-guest interactions have been widely explored in the field of cancer immunotherapy as the delivery systems. A variety of supramolecular materials show unique features for efficient drug encapsulation, targeting delivery and release, which are favorable to activate antitumor immune responses especially through combination of different treatment strategies.
