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- The initiation of protein synthesis is the process that results in bringing together an 80S ribosome with a messenger RNA (mRNA) and initiator methionyl-transfer RNA (Met-tRNA i).
www.ncbi.nlm.nih.gov/pmc/articles/PMC6280705/
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What initiation factors are involved in protein synthesis?
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There are at least 12 dedicated proteins, termed eukaryotic initiation factors (eIFs), that each play critical roles in the process, and several of these factors are comprised of multisubunit proteins. Why so involved, when prokaryotes initiate translation using just three factors ( Rodnina 2018 )?
- Figure 2
Structural models of eukaryotic initiation factor (eIF)3. A...
- Table 1
This review summarizes our current understanding of the...
- PMC Free Article
A non-AUG translational initiation in c-myc exon 1 generates...
- PubMed
We describe the major scanning or messenger RNA (mRNA) m 7 G...
- Figure 2
Jul 17, 2023 · Protein factors– the process of protein synthesis requires multiple non-ribosomal proteins that transiently participate during the initiation, elongation, and termination phases of protein synthesis.
- Jacob E. Hoerter, Steven R. Ellis
- 2023/07/17
- 2021
Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression.
- Richard J. Jackson, Christopher U. T. Hellen, Tatyana V. Pestova
- 2010
Jan 30, 2023 · Initiation of Translation. Protein synthesis begins with the formation of an initiation complex. In E. coli, this complex involves the small 30S ribosome, the mRNA template, three initiation factors (IFs; IF-1, IF-2, and IF-3), and a special initiator tRNA, called tRNA Metf.
Jul 8, 2022 · The process of translation can be divided into four main phases: initiation, elongation, termination, and ribosome recycling. During the initiation phase, eukaryotic translation initiation factors (eIFs) promote the assembly of 80S ribosomes at the AUG start codon with an initiator methionyl-tRNA bound to the P site (Table 1 ).
- Sandra Blanchet, Namit Ranjan
- 2022/07/08
- 10.1007/978-1-0716-2501-9_13
Dec 3, 2018 · We describe the major scanning or messenger RNA (mRNA) m 7 G cap-dependent mechanism, which is a highly coordinated and stepwise regulated process that requires the combined action of at least 12 distinct translation factors with initiator transfer RNA (tRNA), ribosomes, and mRNAs.
In response to nutrients, energy status in the cell, oxygen availability, hormones, and growth factors, mTORC1 phosphorylates a number of factors implicated in translation, including 4E-BPs, ribosomal protein S6 kinase (S6Ks), PDCD4, eIF4B, LARP1, and eEF2 kinase.
