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Jul 17, 2023 · Protein factors– the process of protein synthesis requires multiple non-ribosomal proteins that transiently participate during the initiation, elongation, and termination phases of protein synthesis.
- Jacob E. Hoerter, Steven R. Ellis
- 2023/07/17
- 2021
This review summarizes our current understanding of the major pathway for the initiation phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe the major scanning or messenger RNA (mRNA) m7G cap-dependent ...
Feb 23, 2024 · Initiation typically involves the small ribosomal subunit binding to the mRNA, guided by initiation factors, and scanning for the start codon (usually AUG).
Feb 16, 2021 · In bacteria, three translation initiation factors — initiation factor 1 (IF1), IF2 and IF3 — help to recruit initiator tRNA and to localize the start codon on the message 41.
- Eva Kummer, Nenad Ban
- 2021
Jul 21, 2013 · These structures offer insight into the contributions of the initiation factors, the mechanism by which mRNA is scanned, and the interactions that occur in the ribosome's P site.
- Ivan B. Lomakin, Thomas A. Steitz, Thomas A. Steitz
- 2013
Transcription and RNA processing are followed by translation, the synthesis of proteins as directed by mRNA templates. Proteins are the active players in most cell processes, implementing the myriad tasks that are directed by the information encoded in genomic DNA.
Dec 3, 2018 · We describe the major scanning or messenger RNA (mRNA) m 7 G cap-dependent mechanism, which is a highly coordinated and stepwise regulated process that requires the combined action of at least 12 distinct translation factors with initiator transfer RNA (tRNA), ribosomes, and mRNAs. We limit our review to studies involving either mammalian or ...
