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IF1, IF2, and IF3
- Protein synthesis initiation is triggered by the presence of several initiation factors IF1, IF2, and IF3, including mRNA, ribosomes, tRNA. The small subunit binds to the upstream on the 5′ end at the start of mRNA. The ribosome scans the mRNA in the 5′ to 3′ direction until it encounters the start codon (AUG or GUG or UUG).
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Jul 17, 2023 · Protein factors– the process of protein synthesis requires multiple non-ribosomal proteins that transiently participate during the initiation, elongation, and termination phases of protein synthesis. These factors are named for the phase in which they function (for example, eukaryotic initiation factor 2, eIF2).
- Jacob E. Hoerter, Steven R. Ellis
- 2023/07/17
- 2021
The initiation of protein synthesis is the process that results in bringing together an 80S ribosome with a messenger RNA (mRNA) and initiator methionyl-transfer RNA (Met-tRNA i).
Just as with mRNA synthesis, protein synthesis can be divided into three phases: initiation, elongation, and termination. In addition to the mRNA template, many other molecules contribute to the process of translation, such as ribosomes, tRNAs, and various enzymatic factors
The initiation of protein synthesis consists in the recruitment of a ribosome·initiator tRNA complex to the initiation codon of a messenger RNA. In prokaryotes, this process involves the direct interaction of the ribosomal RNA with the mRNA.
- Francis Poulin, Nahum Sonenberg
- 2013
- 2013
Transcription and RNA processing are followed by translation, the synthesis of proteins as directed by mRNA templates. Proteins are the active players in most cell processes, implementing the myriad tasks that are directed by the information encoded in genomic DNA.
- Geoffrey M Cooper
- 2000
- 2000
Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression.
Jul 21, 2013 · These structures offer insight into the contributions of the initiation factors, the mechanism by which mRNA is scanned, and the interactions that occur in the ribosome's P site.
