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- The initiation of protein synthesis is the process that results in bringing togetheran 80S ribosome with a messenger RNA (mRNA) and initiator methionyl-transfer RNA (Met-tRNAi).
cshperspectives.cshlp.org/content/10/12/a033092.full.pdf
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This review summarizes our current understanding of the major pathway for the initiation phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe the major scanning or messenger RNA (mRNA) m7G cap-dependent ...
- Translate to divide: сontrol of the cell cycle by protein ...
Protein synthesis underpins much of cell growth and,...
- Protein Synthesis Initiation in Eukaryotic Cells - PubMed
We describe the major scanning or messenger RNA (mRNA) m 7 G...
- The structure and function of initiation factors in ...
Protein synthesis is one of the most complex cellular...
- Translate to divide: сontrol of the cell cycle by protein ...
Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression.
- Richard J. Jackson, Christopher U. T. Hellen, Tatyana V. Pestova
- 2010
Apr 4, 2015 · Protein synthesis underpins much of cell growth and, consequently, cell multiplication. Understanding how proliferating cells commit and progress into the cell cycle requires knowing not only which proteins need to be synthesized, but also what determines their rate of synthesis during cell division.
- Michael Polymenis, Rodolfo Aramayo
- 10.15698/mic2015.04.198
- 2015
- Microb Cell. 2015 Apr 6; 2(4): 94-104.
Initiation of Translation. Protein synthesis begins with the formation of an initiation complex. In E. coli, this complex involves the small 30S ribosome, the mRNA template, three initiation factors (IFs; IF-1, IF-2, and IF-3), and a special initiator tRNA, called tRNA Metf.
Dec 3, 2018 · We describe the major scanning or messenger RNA (mRNA) m 7 G cap-dependent mechanism, which is a highly coordinated and stepwise regulated process that requires the combined action of at least 12 distinct translation factors with initiator transfer RNA (tRNA), ribosomes, and mRNAs.
- William C. Merrick, Graham D. Pavitt
- 2018
We outline two main approaches to the proteomic mapping of cell division: first, affinity-based purifications, based on the strength of protein–protein interactions; and second, proximity-based purifications, based on the spatiotemporal localization of the protein of interest.
Oct 28, 1999 · Protein synthesis is one of the most complex cellular processes, involving numerous translation components that interact in multiple sequential steps. The most complex stage in protein synthesis is the initiation process. It involves initiation factor-mediated assembly of a 40S ribosomal subunit and initiator tRNA into a 48S initiation complex ...
