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- We describe the major scanning or messenger RNA (mRNA) m 7 G cap-dependent mechanism, which is a highly coordinated and stepwise regulated process that requires the combined action of at least 12 distinct translation factors with initiator transfer RNA (tRNA), ribosomes, and mRNAs.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6280705/
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The ribosome, the aminoacylated and formylated initiator tRNA (fMet-tRNA f Met), mRNA, and the three protein factors, initiation factor IF1, initiation factor IF2, and initiation factor IF3, are involved in the translation initiation phase (Fig. (Fig.1 1).
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IF2 Interactions with fMet-tRNA f Met and the ribosome. (A)...
- Fig.7 7
Initiation factor IF1 and structural homologues. (A)...
- PMC Free Article
Translation initiation in bacteria involves a stochastic...
- Preferential Translation of Cold-Shock mRNAs During Cold Adaptation
The present results indicate that more than one control...
- Post-termination Complex Disassembly by Ribosome Recycling Factor, a Functional tRNA Mimic
Fig.1. Release of deacylated tRNA from the model...
- Rna Folding Kinetics Regulates Translation of Phage Ms2 Maturation Gene
The gene for the maturation protein of the single-stranded...
- Translation Initiation Factor If1 is Essential for Cell Viability in Escherichia Coli
Translation initiation factor IF1 is a highly conserved...
- Evidence for in Vivo Ribosome Recycling, The Fourth Step in Protein Biosynthesis
Ribosome recycling factor (RRF) catalyzes the fourth step of...
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We present a detailed description of current knowledge about the structure, function, and interactions of the individual components involved in bacterial translation initiation. The first section describes the ribosomal features relevant to the initiation process.
The first section describes the ribosomal features relevant to the initiation process. Subsequent sections describe the structure, function, and interactions of the mRNA, the initiator tRNA, and the initiation factors IF1, IF2, and IF3.
- Brian Søgaard Laursen, Hans Peter Sørensen, Kim Kusk Mortensen, Hans Uffe Sperling-Petersen
- 2005
Jul 17, 2023 · Protein factors– the process of protein synthesis requires multiple non-ribosomal proteins that transiently participate during the initiation, elongation, and termination phases of protein synthesis.
- Jacob E. Hoerter, Steven R. Ellis
- 2023/07/17
- 2021
Jan 1, 2024 · The first one introduces the general steps of protein synthesis in prokaryotes, with a focus on mechanistic details of translation initiation, elongation, termination and ribosome recycling, and on the functional roles of individual translation factors involved in these steps.
Jul 21, 2013 · These structures offer insight into the contributions of the initiation factors, the mechanism by which mRNA is scanned, and the interactions that occur in the ribosome's P site.
The process of translation, or protein synthesis, the second part of gene expression, involves the decoding by a ribosome of an mRNA message into a polypeptide product. The Genetic Code. Translation of the mRNA template converts nucleotide-based genetic information into the “language” of amino acids to create a protein product.
