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  1. Samantha "Sammi" Slott is a former main character in the fourth and fifth seasons of the US version of Shameless. She is the oldest daughter of Frank Gallagher through his relationship with Queenie Slott, revealed when sought out by Frank when he needs a liver transplant corroded by his alcoholism. Though Sammi is initially distraught by the ...

    • Emmy Rossum (Fiona Gallagher) As Fiona Gallagher, the oldest sibling who took on most of the responsibilities in the multi-child house, Emmy Rossum played her most well-known role to date in Shameless, and it was certainly the one she played the longest too.
    • Joan Cusack (Sheila Jackson) In her Emmy-winning role as Sheila Jackson, Joan Cusack played a memorable part in Shameless as the kind and caring (if somewhat absent-minded) mother of Karen.
    • Justin Chatwin (Steve Wilton/Jimmy Lishman/Jack) Playing Jimmy Lishman, who also went by the names Steve Wilton and "Jack," Justin Chatwin played a prominent part in Shameless Seasons 1-3.
    • Laura Slade Wiggins (Karen Jackson) Throughout the first two seasons of Shameless, Laura Slade Wiggins played the recurring role of Karen Jackson, Lip's friend-with-benefits who found herself suffering frontal-lobe brain damage during the end of her time on the show.
  2. Despite previously trying to give her up, Debbie has ultimately come to love her daughter. Debbie appears to not mind Frank watching Franny, as seen in Season 9. She never met her great-grandmother Peggy Gallagher. She never met her first cousin Chuckie. She never met her aunt Sammi.

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    • Emmy Rossum as Fiona Gallagher. For nine seasons, Rossum played Fiona, the oldest of the five Gallagher children who hail from Chicago's South Side. The star's fierce, mother-figure character took on every challenge her dysfunctional family threw at her as she worked odd jobs to support her siblings.
    • Jeremy Allen White as Lip Gallagher. Lip — fan-favorite and second in charge — was played by White throughout all 11 seasons. Since the show's debut in 2011, the star has also appeared in The Time Being (2012), Bad Turn Worse (2013), The Rental (2020), The Birthday Cake (2021) and several shorts.
    • William H. Macy as Frank Gallagher. Macy had a storied career before his role as Frank, an alcoholic absentee father who often serves as the family's constant headache.
    • Steve Howey as Kevin Ball. Howey plays Kevin Ball, the good-natured friend of the Gallagher family and bartender at Frank's favorite neighborhood bar. Before landing Shameless, the actor played Van Montgomery on Reba from 2001 to 2007 and appeared on episodes of New Girl, Sons of Anarchy, Workaholics and Law & Order: SUV while filming the show.
  3. Oct 13, 2021 · In March 2019, Fiona, played by Emmy Rossum, left Shameless after nine seasons on the Showtime drama. After a season of turbulence, Fiona finally got her act together - she went to AA with Lip and sold her stake in a South Side gentrification project for $100K.

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  4. Karen Maguire (née Jackson) is the daughter of Sheila Jackson and her second husband, Eddie. She is married to Jamie Maguire, with who she has a son, Connor. Nigel and Delia Gallagher are her half-brother and sister. Karen Maguire, originally Karen Jackson, was portrayed by Rebecca Atkinson and...

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  6. Apr 11, 2021 · Emma Kenney, 21, has played Debbie Gallagher, one of the middle Gallagher children, since she was 11 years old. Debbie has grown up before our eyes and gone from a young, scrappy kid to a...

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