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   What is PIK3CA gene?

   • PIK3CA is a gene that, when mutated, can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer.

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   What is a PIK3CA mutation in breast cancer?

   • PIK3CA mutations are found in up to 40% of estrogen receptor (ER)-positive, HER2-negative breast cancers. If your tumor is found to have a PIK3CA mutation, new treatments that specifically target the mutation in the PIK3CA gene could be helpful. How are PIK3CA mutations related to metastatic breast cancers?

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   What is PIK3CA treatment?

   • The Food and Drug Administration (FDA) has approved a treatment called alpelisib (Piqray) specifically for people with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative MBC whose tumors have a PIK3CA mutation. What is the PIK3CA gene?

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   Does PIK3CA cause cancer?

   • In addition to playing a role in many breast cancers, PIK3CA mutations have been noted in a dozen other cancers, particularly uterine cancer, bladder cancer, colon cancer, and head and neck cancers.

   PIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com/pik3ca-mutations-in-metastatic-breast-cancer-4689488

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   How does PIK3CA affect breast cancer cells?

   • Evading cell death: PIK3CA mutations are thought to be associated with breast cancer cell's ability to evade programmed cell death (apoptosis). Ability to spread: PIK3CA mutations (the proteins produced) may enhance the ability of cancer cells to break free and migrate to other regions (metastasis).

   PIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com/pik3ca-mutations-in-metastatic-breast-cancer-4689488

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   How does a PIK3CA test work?

   • For this test, a healthcare professional either takes a blood sample or a small amount of cancer tissue from your tumor and sends it to a lab. If the test results show the presence of a mutation in the PIK3CA gene in the cancer tissue, you are eligible for treatment with alpelisib (Piqray).

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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2. www.healthline.com › health › metastatic-breastPIK3CA Mutation in Metastatic Cancer: Treatment and More

   www.healthline.com › health › metastatic-breast

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   Mar 1, 2024 · PIK3CA mutations are found in up to 40% of estrogen receptor (ER)-positive, HER2-negative breast cancers. If your tumor is found to have a PIK3CA mutation, new treatments that...

   • Author: Jacquelyn Cafasso

3. www.verywellhealth.com › pik3ca-mutations-inPIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com › pik3ca-mutations-in

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   Feb 2, 2024 · PIK3 (phosphoinositide 3-kinase), the protein produced by this gene, is part of a signaling pathway that has been studied extensively in the hope of halting the growth of metastatic breast cancer.

4. Videos

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     Why Do Cancers Have PIK3CA Mutations and How Can They Be Targeted for Cancer Treatment?

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     The PI3K Signaling Pathway

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     Dr. Hurvitz on Patient Outcomes and PIK3CA Mutations

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5. www.knowyourbiomarker.org › biomarkers › pik3caPIK3CA Mutation - Know Your Biomarker

   www.knowyourbiomarker.org › biomarkers › pik3ca

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   What is PIK3CA? PIK3CA is a gene that encodes one piece (a subunit) of an enzyme called phosphatidylinositol 3-kinase. PIK3CA plays a role in the way cell growth, cell survival, and cell migration are controlled. Mutations in the PIK3CA gene can lead to uncontrolled cell growth and may cause cancer as well as some rare diseases of abnormal growth.

6. medlineplus.gov › genetics › genePIK3CA gene - MedlinePlus

   medlineplus.gov › genetics › gene

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   The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). Learn about this gene and related health conditions.

7. pmc.ncbi.nlm.nih.gov › articles › PMC8664971A standard of care for individuals with PIK3CA-related ...

   pmc.ncbi.nlm.nih.gov › articles › PMC8664971

   Keywords: PIK3CA-related overgrowth spectrum, clinical management, mosaic, expert consensus. INTRODUCTION. Activating variants in PIK3CA cause a phenotypic spectrum of developmental disorders known as the PIK3CA-Related Overgrowth Spectrum (PROS) (1-10). Deep sequencing technologies have facilitated the identification and clinical testing for ...

8. pubmed.ncbi.nlm.nih.gov › 34240408A standard of care for individuals with PIK3CA-related ...

   pubmed.ncbi.nlm.nih.gov › 34240408

   These phenotypically heterogeneous entities have been grouped as PIK3CA-Related Overgrowth Spectrum disorders (PROS). Deep sequencing technologies have facilitated detection of low-level mosaic, often necessitating testing of tissues other than blood.

9. www.cancer.gov › cancer-terms › defDefinition of PIK3CA gene - NCI Dictionary of Cancer Terms

   www.cancer.gov › cancer-terms › def

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   A gene that makes one of the proteins in an enzyme called PI3K, which is involved in many important functions in a cell. Mutations (changes) in the PIK3CA gene may cause the PI3K enzyme to become overactive, which may cause cancer cells to grow.