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Interferes with the brain’s communication pathways
- Alcohol interferes with the brain’s communication pathways and can affect the way the brain looks and works. Alcohol makes it harder for the brain areas controlling balance, memory, speech, and judgment to do their jobs, resulting in a higher likelihood of injuries and other negative outcomes.
www.niaaa.nih.gov/publications/alcohol-and-brain-overviewAlcohol and the Brain: An Overview | National Institute on ...
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ALK-positive lung cancer is a type of non-small cell lung cancer (NSCLC) in which there is an abnormal fusion of the anaplastic lymphoma kinase (ALK) gene and another gene, often (about 90%) echinoderm microtubule-associated protein-like 4 (EML4).
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Nov 2, 2018 · The anaplastic lymphoma kinase (ALK) receptor is a membrane-bound tyrosine kinase. The pathogenesis of several cancers is closely related to aberrant forms of ALK or aberrant ALK expression, including ALK fusion proteins, ALK-activated point mutations, and ALK amplification.
- Hao Huang
- 10.3390/ijms19113448
- 2018
- Int J Mol Sci. 2018 Nov; 19(11): 3448.
The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the development of the brain and can be oncogenically altered in several malignancies, including non-small-cell lung cancer (NSCLC) and anaplastic large cell lymphomas (ALCL).
- Vijaykumar R. Holla, Yasir Y. Elamin, Ann Marie Bailey, Amber M. Johnson, Beate C. Litzenburger, Yek...
- 10.1101/mcs.a001115
- 2017
- 2017/01
- How Does Lung Cancer Spread to The Brain?
- Lung Cancer Brain Metastases Symptoms
- Diagnosis
- Treatment
- Palliative Care
- Summary
Lung cancer spreading to the brain is fairly common. Up to 7% of people already have cancer cells in the brain when they are first diagnosed with non-small cell lung cancer(NSCLC), and 20% to 40% of those with NSCLC will develop the complication at some point. About 20% to 40% of patients with non-small cell lung cancer have brain metastases. Brain...
Small cell lung canceris often hard to diagnose in the early stages. It may spread to the brain before a lung cancer diagnosis is even made. Non-small cell cancers can also spread to the brain but tend to do so later in the disease after the primary tumor has been found. Since it's so easy to miss small growths, it's important for people with lung ...
If healthcare providers think that your lung cancer has spread to your brain, they will do imaging tests such as a computed tomography (CT) scan, which uses X-rays to create diagnostic images, or magnetic resonance imaging (MRI), which does the same with magnetic waves While an MRI is considered more accurate, it cannot be used if you have certain ...
Treatments for brain metastases are not considered cures. The goal is to reduce pain and increase how long you can live with lung cancer that has spread to the brain. However, that does not mean that these treatments won’t make a positive difference in your quality of life, or even your life expectancy. For example, studies have shown that people w...
The five-year relative survival rates for non-small cell lung cancer and small cell lung cancer that has metastasized to the brain are 7% and 3%, respectively. However, these survival rates can be better for some people thanks to earlier diagnoses and more treatments. If different treatments are tried and have not helped, you may choose palliative ...
When lung cancer spreads (metastasis) it’s common for it to go to the brain. If you have lung cancer, you should know the signs of brain metastases. You may have treatment options that could help prevent the spread and help with your symptoms. Treatments mean that even though brain metastasis will affect your life expectancy with lung cancer, you m...
Alkaline phosphatase (AP), an enzyme first discovered in the 1920s, has been evaluated as a potential biomarker in many disorders, including many of the co-morbidities associated with stroke.
- Allison L. Brichacek, Candice M. Brown
- 10.1007/s11011-018-0322-3
- 2019
- 2019/02
Nov 24, 2021 · Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates important functions in the central nervous system 1, 2. The ALK gene is a hotspot for chromosomal...
Jan 18, 2022 · In this retrospective study, ALK-positive NSCLC patients with brain metastases (BM) or leptomeningeal metastases (LM) from six hospitals in China were divided into three cohorts based on the treatment history before the administration of alectinib.
