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- In 1908 Ehrlich shared the Nobel Prize in Physiology or Medicine with Élie Metchnikoff for their separate paths to an understanding of the immune response: Ehrlich presented a chemical theory to explain the formation of antitoxins, or antibodies, to fight the toxins released by the bacteria, while Metchnikoff studied the role of white blood corpuscles (phagocytes) in destroying bacteria themselves.
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Jul 1, 2008 · Both Ehrlich and Metchnikoff provided a paradigm shift by developing concepts of how the host can deal with invading pathogens to overcome infectious disease.
- Stefan H E Kaufmann
- 2008
Élie Metchnikoff was a Russian-born zoologist and microbiologist who received (with Paul Ehrlich) the 1908 Nobel Prize for Physiology or Medicine for his discovery in animals of amoeba-like cells that engulf foreign bodies such as bacteria—a phenomenon known as phagocytosis and a fundamental part.
- The Editors of Encyclopaedia Britannica
Paul Ehrlich not only developed the concept of the side-chain theory of antibody formation but also discovered the first chemotherapeutic agent against microbial pathogens through a combination of chemical modification of a lead substance and experimental animal screening on a broad-scale.
- Stefan H. E. Kaufmann
- 2008
Elie Metchnikoff’s and Paul Ehrlich’s impact on infection biology. Microbes Infect (2008) 10:1417–9. 10.1016/j.micinf.2008.08.012 [Google Scholar] 7. Chang ZL. Recent development of the mononuclear phagocyte system: in memory of Metchnikoff and Ehrlich on the 100th Anniversary of the 1908 Nobel Prize in Physiology or Medicine.
Apr 4, 2020 · In 1908 Ehrlich shared the Nobel Prize in Physiology or Medicine with Élie Metchnikoff for their separate paths to an understanding of the immune response: Ehrlich presented a chemical theory to explain the formation of antitoxins, or antibodies, to fight the toxins released by the bacteria, while Metchnikoff studied the role of white blood ...
Nov 1, 2008 · Metchnikoff compared microphages with herbivores and macrophages with carnivores and proposed that both types of phagocytes contribute to defence but in varying proportions in different infectious diseases.
Metchnikoff discovered phagocytosis by macrophages and microphages as a critical host-defense mechanism and thus is considered the father of cellular innate immunity. Ehrlich described the...
