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Jul 1, 2008 · Both Ehrlich and Metchnikoff provided a paradigm shift by developing concepts of how the host can deal with invading pathogens to overcome infectious disease.
- Stefan H E Kaufmann
- 2008
Elie Metchnikoff was not only the first to describe phagocytosis of invading pathogens by specialized blood cells - macrophages and neutrophils - he also was interested in the impact of normal flora on well-being and in pre- and probiotic diet and their influence on the normal flora.
- Stefan H. E. Kaufmann
- 2008
Elie Metchnikoff’s and Paul Ehrlich’s impact on infection biology. Microbes Infect (2008) 10:1417–9. 10.1016/j.micinf.2008.08.012 [Google Scholar] 7. Chang ZL. Recent development of the mononuclear phagocyte system: in memory of Metchnikoff and Ehrlich on the 100th Anniversary of the 1908 Nobel Prize in Physiology or Medicine.
Nov 1, 2008 · Through his work on toxin neutralization, Ehrlich became interested in host defence against infectious agents and in 1890 he was ready to translate the side-chain theory from specific nutrient uptake into antibody formation.
- Stefan H. E. Kaufmann
- 2008
After Pasteur’s initial hypotheses to account for immunity, two competing breakthroughs occurred: Eli Metchnikoff’s discovery of macrophage-mediated phagocytosis, and Paul Ehrlich’s discovery of antigen-specific antibody responses . Unsurprisingly, the antibody response became the dominant paradigm, because it paved the way for the study ...
Metchnikoff is rightly famous for his recognition of the biological significance of leukocyte recruitment and phagocytosis of microbes in host defence against infection, inflammation and immunity. As a comparative zoologist he utilised a broad range of model organisms for microscopic studies in vivo and in vitro.
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Metchnikoff discovered phagocytosis by macrophages and microphages as a critical host-defense mechanism and thus is considered the father of cellular innate immunity. Ehrlich described the...
