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- In the mid-1870s, pathogenic bacteria were identified as the aetiological agents of infectious diseases. This momentous discovery (see Timeline) gave birth to several modern disciplines: microbiology, inflammatory pathology, infectious disease as a medical discipline, and — most importantly for Metchnikoff's story — immunology.
www.nature.com/articles/nrm1244Metchnikoff and the phagocytosis theory | Nature Reviews ...
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Jul 1, 2008 · Metchnikoff discovered phagocytosis by macrophages and microphages as a critical host-defense mechanism and thus is considered the father of cellular innate immunity.
- Stefan H E Kaufmann
- 2008
The 100th anniversary of the Nobel Prize for Medicine to Paul Ehrlich and Elie Metchnikoff gives us a good opportunity to reflect on their research about infectious diseases. Elie Metchnikoff was not only the first to describe phagocytosis of invading pathogens by specialized blood cells - macrophag ….
- Stefan H. E. Kaufmann
- 2008
After Pasteur’s initial hypotheses to account for immunity, two competing breakthroughs occurred: Eli Metchnikoff’s discovery of macrophage-mediated phagocytosis, and Paul Ehrlich’s discovery of antigen-specific antibody responses . Unsurprisingly, the antibody response became the dominant paradigm, because it paved the way for the study ...
Nov 1, 2008 · Metchnikoff compared microphages with herbivores and macrophages with carnivores and proposed that both types of phagocytes contribute to defence but in varying proportions in different infectious diseases.
- Stefan H. E. Kaufmann
- 2008
Elie Metchnikoff’s and Paul Ehrlich’s impact on infection biology. Microbes Infect (2008) 10:1417–9. 10.1016/j.micinf.2008.08.012 [Google Scholar] 7. Chang ZL. Recent development of the mononuclear phagocyte system: in memory of Metchnikoff and Ehrlich on the 100th Anniversary of the 1908 Nobel Prize in Physiology or Medicine.
Metchnikoff is rightly famous for his recognition of the biological significance of leukocyte recruitment and phagocytosis of microbes in host defence against infection, inflammation and immunity. As a comparative zoologist he utilised a broad range of model organisms for microscopic studies in vivo and in vitro.
Apr 4, 2020 · In 1908 Ehrlich shared the Nobel Prize in Physiology or Medicine with Élie Metchnikoff for their separate paths to an understanding of the immune response: Ehrlich presented a chemical theory to explain the formation of antitoxins, or antibodies, to fight the toxins released by the bacteria, while Metchnikoff studied the role of white blood ...
