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   What causes familial Mediterranean fever?

   • Familial Mediterranean fever is caused by a gene change (mutation) that's passed from parents to children. The gene change affects the function of an immune system protein called pyrin, causing problems in regulating inflammation in the body. In people with FMF, change occurs in a gene called MEFV. Many different changes in MEFV are linked to FMF.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   What are the symptoms of familial Mediterranean fever?

   • Symptoms of familial Mediterranean fever usually begin between the ages of 5 and 15 years. The most common symptoms are Attacks of abdominal pain occur in about 95% of people. Attacks happen irregularly and are accompanied by fever as high as 104° F (40° C).

   Familial Mediterranean Fever - The Merck Manuals

   www.merckmanuals.com/home/children-s-health-issues/hereditary-periodic-fever-syndromes/familial-mediterranean-fever

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   Is Mediterranean fever inherited?

   • FMF is a recessive autosomal disorder, meaning that it is inherited from one’s parents. The disease is associated with mutations in the Mediterranean fever (MEFV) gene, of which there are more than 30 variations. For a person to experience symptoms, they would need to have inherited copies of the mutation from both parents.

   Overview of Familial Mediterranean Fever - Verywell Health

   www.verywellhealth.com/familial-mediterranean-fever-4159712

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   What is familial Mediterranean fever (FMF)?

   • Familial Mediterranean fever (FMF) is an inherited disorder that usually occurs in people of Mediterranean origin — including those of Jewish, Arab, Armenian, Turkish, North African, Greek or Italian ancestry. But it can affect people in any ethnic group. FMF is typically diagnosed during childhood.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   Can familial Mediterranean fever be cured?

   • FMF is typically diagnosed during childhood. While there's no cure for this disorder, you may be able to relieve or even prevent signs and symptoms of FMF by following your treatment plan. Signs and symptoms of familial Mediterranean fever usually begin during childhood. They occur in bouts called attacks that last 1-3 days.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   When does a child develop Mediterranean fever?

   • Two-thirds of patients develop symptoms before the age of 5 years and 90% by 20 years of age. Familial Mediterranean fever is usually inherited as an autosomal recessive condition, meaning both parents must carry the defective gene and there is a one in four chance of a child being affected (MIM 249100).

   Familial Mediterranean fever - DermNet

   dermnetnz.org/topics/familial-mediterranean-fever

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2. www.mayoclinic.org › symptoms-causes › syc-20372470Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org › symptoms-causes › syc-20372470

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   Nov 11, 2021 · Familial Mediterranean fever is caused by a gene change (mutation) that's passed from parents to children. The gene change affects the function of an immune system protein called pyrin, causing problems in regulating inflammation in the body. In people with FMF, change occurs in a gene called MEFV.

3. bestpractice.bmj.com › topics › en-gbFamilial Mediterranean fever - Symptoms, diagnosis and ...

   bestpractice.bmj.com › topics › en-gb

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   Sep 30, 2010 · Characterised by recurrent attacks of fever and systemic inflammation, typically lasting 24-72 hours and presenting in childhood. Rare manifestations include chronic arthritis, spondyloarthropathy, myopathies, and protracted febrile myalgia.

4. www.verywellhealth.com › familial-mediterraneanOverview of Familial Mediterranean Fever - Verywell Health

   www.verywellhealth.com › familial-mediterranean

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   Jul 16, 2023 · Familial Mediterranean fever is a rare inherited disorder seen in some ethnic groups that causes bouts of fever, chest pain, stomach pain, and arthritis.

5. www.ncbi.nlm.nih.gov › books › NBK560754Familial Mediterranean Fever - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK560754

   Jul 31, 2023 · Familial Mediterranean fever (FMF) also known as 'periodic peritonitis,' 'familial paroxysmal polyserositis,' 'periodic disease,' 'Siegal-Cattan-Mamou disease,' 'Wolff periodic disease' or 'Reimann syndrome' is an autoinflammatory genetic disorder that causes recurrent fevers and serosal inflammation of the abdomen, lungs, and joints leading to ...

   • Author: Harshil Bhatt, Marco Cascella
   • Published: 2023/07/31

   • Publish Year: 2021

6. dermnetnz.org › topics › familial-mediterranean-feverFamilial Mediterranean fever - DermNet

   dermnetnz.org › topics › familial-mediterranean-fever

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   Familial Mediterranean fever is an inherited autoinflammatory syndrome characterised by recurrent short episodes of high fever associated with abdominal pain, inflammation of joints and other body sites and skin rash. If untreated, amyloidosis commonly develops and may have a fatal outcome.

7. rarediseases.org › familial-mediterranean-feverFamilial Mediterranean Fever - Symptoms, Causes, Treatment - NORD

   rarediseases.org › familial-mediterranean-fever

   Apr 25, 2024 · Familial Mediterranean fever (FMF) is an inherited autoinflammatory disease characterized by recurrent episodes (attacks) of fever and acute inflammation of the membranes lining the abdomen, joints and lungs.

8. www.merckmanuals.com › home › children-s-healthFamilial Mediterranean Fever - Familial Mediterranean Fever ...

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   Familial Mediterranean fever is a hereditary disorder characterized by episodes of high fever with abdominal pain or, less commonly, chest pain, joint pain, or a rash. Familial Mediterranean fever is caused by a gene inherited from both parents. Typically, most people have attacks of severe abdominal pain and a high fever.