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   What causes familial Mediterranean fever?

   • Familial Mediterranean fever is caused by a gene change (mutation) that's passed from parents to children. The gene change affects the function of an immune system protein called pyrin, causing problems in regulating inflammation in the body. In people with FMF, change occurs in a gene called MEFV. Many different changes in MEFV are linked to FMF.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   Is Mediterranean fever inherited?

   • FMF is a recessive autosomal disorder, meaning that it is inherited from one’s parents. The disease is associated with mutations in the Mediterranean fever (MEFV) gene, of which there are more than 30 variations. For a person to experience symptoms, they would need to have inherited copies of the mutation from both parents.

   Overview of Familial Mediterranean Fever - Verywell Health

   www.verywellhealth.com/familial-mediterranean-fever-4159712

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   What is familial Mediterranean fever (FMF)?

   • Familial Mediterranean fever (FMF) is an inherited disorder that usually occurs in people of Mediterranean origin — including those of Jewish, Arab, Armenian, Turkish, North African, Greek or Italian ancestry. But it can affect people in any ethnic group. FMF is typically diagnosed during childhood.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   Is there a cure for familial Mediterranean fever?

   • At present, there is no known cure for Familial Mediterranean Fever (FMF). Physicians can only treat the symptoms of the disease. A common therapy for FMF is daily use of the drug colchicine, a medicine that reduces inflammation.

   About Familial Mediterranean Fever - National Human Genome Research

   www.genome.gov/Genetic-Disorders/Familial-Mediterranean-Fever

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   What are the signs and symptoms of familial Mediterranean fever?

   • Signs and symptoms of familial Mediterranean fever usually begin during childhood. They occur in bouts called attacks that last 1-3 days. Arthritic attacks may last for weeks or months. Signs and symptoms of FMF attacks vary, but can include: The attacks generally resolve spontaneously after a few days.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   What is MEFV disease?

   • The genetic definition is disease caused by Mendelian-recessive inheritance due to mutations in the Mediterranean fever (MEFV) gene coding for a protein named marenostrin/pyrin. MEFV gene analysis is the only objective tool that confirms the diagnosis of FMF. However, MEFV carriers sometimes present with FMF-like disease.

   Familial Mediterranean fever - Symptoms, diagnosis and treatment | BMJ

   bestpractice.bmj.com/topics/en-gb/1163

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2. www.mayoclinic.org › diseases-conditions › familialFamilial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › familial

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   Nov 11, 2021 · Familial Mediterranean fever is caused by a gene change (mutation) that's passed from parents to children. The gene change affects the function of an immune system protein called pyrin, causing problems in regulating inflammation in the body. In people with FMF, change occurs in a gene called MEFV.

3. bestpractice.bmj.com › topics › en-gbFamilial Mediterranean fever - Symptoms, diagnosis and ...

   bestpractice.bmj.com › topics › en-gb

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   Sep 30, 2010 · Familial Mediterranean fever is primarily a genetic disease due to Mendelian-recessive inheritance of Mediterranean fever gene mutations. Occurs mainly in people of Mediterranean ancestry, especially from Arab countries, Turkey, Israel, and Armenia. Characterised by recurrent attacks of fever and...

4. www.verywellhealth.com › familial-mediterraneanOverview of Familial Mediterranean Fever - Verywell Health

   www.verywellhealth.com › familial-mediterranean

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   Jul 16, 2023 · Familial Mediterranean fever is a rare inherited disorder seen in some ethnic groups that causes bouts of fever, chest pain, stomach pain, and arthritis.

5. en.wikipedia.org › wiki › Familial_Mediterranean_feverFamilial Mediterranean fever - Wikipedia

   en.wikipedia.org › wiki › Familial_Mediterranean_fever

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   Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. [1]: 149 FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid protein called pyrin. [2]

6. www.ncbi.nlm.nih.gov › books › NBK560754Familial Mediterranean Fever - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK560754

   Jul 31, 2023 · Familial Mediterranean fever (FMF) is an autoinflammatory genetic disorder that mainly affects people of Mediterranean origin. FMF is characterized by recurrent episodes of fever and serositis (chest, abdomen, joints), leading to painful attacks early during childhood.

   • Author: Harshil Bhatt, Marco Cascella
   • Published: 2023/07/31

   • Publish Year: 2021

7. pmc.ncbi.nlm.nih.gov › articles › PMC7672358Familial Mediterranean fever, from pathogenesis to treatment ...

   pmc.ncbi.nlm.nih.gov › articles › PMC7672358

   Familial Mediterranean fever (FMF) (OMIM #249100) is the most common hereditary autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV gene which encodes an immune regulatory protein, pyrin.

8. www.genome.gov › Familial-Mediterranean-FeverAbout Familial Mediterranean Fever - National Human Genome ...

   www.genome.gov › Familial-Mediterranean-Fever

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   Jun 29, 2017 · Familial Mediterranean Fever (FMF) is an autosomal recessive inherited disease, which means it appears only in individuals who received two copies of the mutant (altered) gene that causes FMF, one from each parent.