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   What causes familial Mediterranean fever?

   • Familial Mediterranean fever is caused by a gene change (mutation) that's passed from parents to children. The gene change affects the function of an immune system protein called pyrin, causing problems in regulating inflammation in the body. In people with FMF, change occurs in a gene called MEFV. Many different changes in MEFV are linked to FMF.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   What is familial Mediterranean fever (FMF)?

   • Familial Mediterranean fever (FMF) is an inherited disorder that usually occurs in people of Mediterranean origin — including those of Jewish, Arab, Armenian, Turkish, North African, Greek or Italian ancestry. But it can affect people in any ethnic group. FMF is typically diagnosed during childhood.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   Is Mediterranean fever inherited?

   • FMF is a recessive autosomal disorder, meaning that it is inherited from one’s parents. The disease is associated with mutations in the Mediterranean fever (MEFV) gene, of which there are more than 30 variations. For a person to experience symptoms, they would need to have inherited copies of the mutation from both parents.

   Overview of Familial Mediterranean Fever - Verywell Health

   www.verywellhealth.com/familial-mediterranean-fever-4159712

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   What are the signs and symptoms of familial Mediterranean fever?

   • Signs and symptoms of familial Mediterranean fever usually begin during childhood. They occur in bouts called attacks that last 1-3 days. Arthritic attacks may last for weeks or months. Signs and symptoms of FMF attacks vary, but can include: The attacks generally resolve spontaneously after a few days.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   Can familial Mediterranean fever be cured?

   • FMF is typically diagnosed during childhood. While there's no cure for this disorder, you may be able to relieve or even prevent signs and symptoms of FMF by following your treatment plan. Signs and symptoms of familial Mediterranean fever usually begin during childhood. They occur in bouts called attacks that last 1-3 days.

   Familial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/familial-mediterranean-fever/symptoms-causes/syc-20372470

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   Is Mediterranean fever autosomal dominant?

   • There is a less common autosomal dominant form (MIM 134610). Familial Mediterranean fever is usually due to mutations in the Mediterranean fever (MEFV) or pyrin gene located on chromosome 16 (16p13.3). Mutations in the MEFV gene have been found in 80% of typical cases. More than 100 different disease-linked mutations have been identified.

   Familial Mediterranean fever - DermNet

   dermnetnz.org/topics/familial-mediterranean-fever

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2. www.mayoclinic.org › diseases-conditions › familialFamilial Mediterranean fever - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › familial

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   Nov 11, 2021 · Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder that causes recurrent fevers and painful inflammation of your abdomen, chest and joints.

3. bestpractice.bmj.com › topics › en-gbFamilial Mediterranean fever - Symptoms, diagnosis and ...

   bestpractice.bmj.com › topics › en-gb

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   Sep 30, 2010 · Familial Mediterranean fever is primarily a genetic disease due to Mendelian-recessive inheritance of Mediterranean fever gene mutations. Occurs mainly in people of Mediterranean ancestry, especially from Arab countries, Turkey, Israel, and Armenia.

4. www.ncbi.nlm.nih.gov › books › NBK560754Familial Mediterranean Fever - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK560754

   Jul 31, 2023 · Familial Mediterranean fever (FMF) is an autoinflammatory genetic disorder that mainly affects people of Mediterranean origin. FMF is characterized by recurrent episodes of fever and serositis (chest, abdomen, joints), leading to painful attacks early during childhood.

   • Author: Harshil Bhatt, Marco Cascella
   • Published: 2023/07/31

   • Publish Year: 2021

5. www.verywellhealth.com › familial-mediterraneanOverview of Familial Mediterranean Fever - Verywell Health

   www.verywellhealth.com › familial-mediterranean

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   Jul 16, 2023 · FMF primarily causes inflammation of the skin, internal organs, and joints. The attacks are characterized by one- to three-day bouts of headache and fever alongside other inflammatory conditions such as: Pleurisy (inflammation of the lining of the lungs; characterized by painful respiration)

6. dermnetnz.org › topics › familial-mediterranean-feverFamilial Mediterranean fever - DermNet

   dermnetnz.org › topics › familial-mediterranean-fever

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   Familial Mediterranean fever is an inherited autoinflammatory syndrome characterised by recurrent short episodes of high fever associated with abdominal pain, inflammation of joints and other body sites and skin rash.

7. rarediseases.org › familial-mediterranean-feverFamilial Mediterranean Fever - Symptoms, Causes, Treatment - NORD

   rarediseases.org › familial-mediterranean-fever

   Apr 25, 2024 · Familial Mediterranean fever (FMF) is an inherited autoinflammatory disease characterized by recurrent episodes (attacks) of fever and acute inflammation of the membranes lining the abdomen, joints and lungs.

8. pmc.ncbi.nlm.nih.gov › articles › PMC7672358Familial Mediterranean fever, from pathogenesis to treatment ...

   pmc.ncbi.nlm.nih.gov › articles › PMC7672358

   Familial Mediterranean fever (FMF) (OMIM #249100) is the most common hereditary autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV gene which encodes an immune regulatory protein, pyrin.