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  2. Occasional side effects. These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). You might have one or more of them. They include: breathlessness and looking pale due to a drop in red blood cells (anaemia) tiredness (fatigue) or drowsiness; headaches

  3. Common side effects. These common side effects of methotrexate may happen in more than 1 in 100 people. There are things you can do to help cope with them: Loss of appetite. Feeling or being sick. Stomach pain or indigestion. Diarrhoea. Headaches. Feeling tired or drowsy.

  4. If you have intrathecal chemotherapy, the side effects you have may be different from the ones listed above. Intrathecal methotrexate can cause: headaches; dizziness; tiredness; blurred vision; loss of balance. These side effects can last for a few hours. If you have any of these, tell your doctor.

  5. The most common side effects of methotrexate are: Sponsor Message. nausea. vomiting. joint pain. diarrhea. swelling in the feet and legs. mouth sores. hair changes. rash. loss of appetite.

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  6. Symptoms of infection include fever, shivering, sweats, sore throat, diarrhoea, discomfort when you pass urine, cough or breathlessness. We recommend that you use a digital thermometer so you can check your temperature. You can buy one from your local chemist.

  7. Oct 4, 2023 · Methotrexate can cause serious or fatal side effects. Tell your doctor if you have diarrhea, mouth sores, cough, shortness of breath, upper stomach pain, dark urine, numbness or tingling, muscle weakness, confusion, seizure, or skin rash that spreads and causes blistering and peeling.

  8. Are there any long-term side effects? Methotrexate may increase the risk of problems with your liver or lungs, especially if you take a high dose. However, your doctor will monitor you very closely while you're taking methotrexate.

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