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Jul 1, 2018 · This shift in paradigm sparked new preclinical and clinical investigations aimed at defining the contribution of sympathetic, parasympathetic, and sensory nerves to the process of bone development, bone mass accrual, bone remodeling, and cancer metastasis.
- Florent Elefteriou
- 2018
The central and peripheral nervous systems tightly regulate compact bone remodeling, its metabolism, and hematopoietic homeostasis in the bone marrow (BM). Accumulating evidence indicates that the nervous system, which fine-tunes inflammatory responses and alterations in neural functions, may regulate autoimmune diseases.
- Maria Maryanovich, Shoichiro Takeishi, Paul S. Frenette
- 10.1101/cshperspect.a031344
- 2018
- 2018/09
Sep 5, 2023 · The hypothalamus, located in the central nervous system (CNS), plays a key role in processing interoceptive signals and regulating bone homeostasis through the autonomic nervous system,...
- Yao Xiao
Jun 16, 2020 · Contrastingly, the presence of the parasympathetic nervous system (PNS), another branch of the SNS, within the BM is vastly unexplored. The PNS uses acetylcholine (ACh) as the main neurotransmitter, which binds to muscarinic or nicotinic receptors.
- Claire Fielding, Claire Fielding, Simón Méndez-Ferrer, Simón Méndez-Ferrer
- 10.12688/f1000research.22554.1
- 2020
- 2020
Jan 1, 2017 · Parasympathetic innervation of the bone marrow was established by Artico et al. (2002) [20], who demonstrated the presence of choline acetyltransferase (ChAT)-immunoreactive nerve fibers around hematopoietic islets in the bone marrow of the rat femur; ChAT synthesizes acetylcholine (ACh), the neurotransmitter used by all parasympathetic neurons.
- Won-Cheol Jung, Jean-Pierre Levesque, Marc J. Ruitenberg
- 2017
Jul 25, 2019 · The role of NPY in the hematopoietic bone marrow niche. Upper panel: NPY protects the hematopoietic environment through interactions with Y1, Y2 receptors on BM-MSCs, OBs, macrophages and ECs. NPY is secreted from sympathetic nerve endings, macrophages, OBs and ECs.
People also ask
What role do sympathetic and parasympathetic neurons play in bone development?
Is there a link between sympathetic and parasympathetic nervous systems?
Where are parasympathetic neurons located?
Does the nervous system regulate hematopoietic homeostasis in bone marrow?
The first is the sympathetic nervous system (SNS) that emerges from the thoracolumbar spinal cord, and pre-pares the body for alert situations by increasing heart rates and the contractility of myocytes, while diverting blood flow away from the gastro-intestinal (GI) tract.
