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  2. Feb 23, 2020 · Vagus nerve stimulation (VNS) therapy is a treatment for epilepsy that involves a stimulator (or 'pulse generator') which is connected, inside the body, to the left vagus nerve in the neck. The stimulator sends regular, mild electrical stimulations through this nerve to help calm down the irregular electrical brain activity that leads to seizures.

  3. Vagus nerve stimulation (VNS) may prevent or lessen seizures by sending regular, mild pulses of electrical energy to the brain via the vagus nerve. The therapy consists of a device that is implanted under the skin in the left chest area.

  4. If you have seizures which can’t be controlled with epilepsy medicines, and you are not able to have epilepsy brain surgery, then vagus nerve stimulation (VNS) therapy may be an option for you. The aim of VNS therapy is to reduce the number of seizures you have and make them less severe.

  5. VNS treatment is an efficacious surgical intervention for patients aged 4 years and older with pharmacoresistant epilepsy who cannot receive or failed resective surgery. After more than two years of VNS, about 8% of patients achieve seizure freedom, and about 50% will have at least 50% reduced seizure frequency. 1.

  6. 1.2 Mechanism of action of vagus nerve stimulation. Therapy-resistant epilepsy patients can benefit from supplementary vagus nerve stimulation (VNS) treatments. Most of the time, it is still unclear how VNS works. One way that VNS works is by way of the tryptophan metabolism route. 1.3 Tryptophan metabolism

  7. Oct 16, 2024 · VNS is a safe and effective therapy for drug-resistant epilepsy. Key brain areas implicated in VNS include the thalamus, amygdala, hippocampus, and insula, among others. Identifying markers of difference in response to VNS within DRE could explain heterogeneity in outcomes.

  8. Jan 14, 2012 · Vagus nerve stimulation (VNS) is a unique epilepsy treatment in that a peripheral intervention is used to treat a disease that is entirely related to pathological events occurring within the brain. To understand how stimulation of the vagus nerve can be used to stop seizures, an understanding of the peripheral anatomy and physiology of the ...

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