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PhD in Medicine, Gastroenterologist, with research focused on Inflammatory Bowel Diseases and their associated environmetal factors, specifically tobacco smoking.
Tiago Nunes MD, PhD has a strong background in clinical development and research. Tiago currently holds the position of Vice President, Clinical Development at Mirum Pharmaceuticals, Inc. and has been with the company since 2020.
- Vice President, Clinical Development
- Mirum Pharmaceuticals, Mirum Pharmaceuticals
Jan 26, 2017 · The lifeless body of little Tiago Nunes was found in bed alongside his mum Adriana and dad Tiago at their cottage on a farm in Reigate, Surrey, on Tuesday.
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Patients not exposed to tobacco before inclusion (non- and former smokers), continuing smokers, and quitters were compared regarding differences in disease outcomes during a follow-up of 4 years ...
- Materials and Methods
- Results
- Discussion
- Acknowledgments
Study Design
To ascertain whether the smoking habit influences CD clinical course we undertook an observational cross-sectional study in a large population of CD patients. The TABACROHN Study was designed and supported by the Spanish Working Group in Crohn's Disease and Ulcerative Colitis (GETECCU) with the participation of 14 Spanish referral IBD units. During a 6-month inclusion period, 1217 consecutive patients with an established diagnosis of CD confirmed by standard radiologi-cal, endoscopic, and his...
Smoking Habit Definitions
The definition of smoking was that of Cosnes et al,18who defined smoking as the consumption of more than 7 cigarettes per week for at least 6 months along with a report of any cigarette smoking in the previous 6 months. Nonsmokers were those who never smoked, had stopped smoking more than 12 months before CD diagnosis, or smoked fewer than 7 cigarettes weekly. Former smokers were patients who were active smokers but had quit at least 12 months before CD diagnosis or thereafter. The lifetime t...
Ethical Issues
All data was anonymously analyzed to preserve patient confidentiality. The study was approved by the Ethics Committee of the Hospital Clinic Provincial of Barcelona, Spain.
TABACROHN Study Population
In all, 1214 patients were included in the TABACROHN study. Forty-four patients were subsequently excluded due to lack of essential data regarding disease phenotype or smoking status, leaving 1170 eligible patients for further analysis. When smoking exposure was assessed, there were 575 patients present or previously exposed to tobacco (49%), including 420 current smokers and 155 former smokers (36% and 13% of the total study population, respectively), and 595 nonsmokers (51%). Regarding the...
Population Characteristics According to Tobacco Load
Current and former smokers with ≥12 pack years of tobacco load presented more stricturing and less inflammatory CD phenotype than patients with <12 pack year (Table 3). In addition, heavy smokers presented a trend toward a higher prevalence of bowel resection when compared to light smokers. Of note, patients with greater tobacco load were more frequently male, older at disease onset and at study inclusion, and presented longer disease duration (Table 3).
Multivariate Analysis
Multiplicative interaction between selected covariates assessed through logistic regression found that being exposed to tobacco is an independent predictor of need for maintenance treatment and, specifically, for biological therapy. In addition, tobacco load, expressed as pack years, was independently associated with stricturing disease (Table 4).
The influence of smoking on CD clinical course has been the subject of intense research, but their results have greatly varied with respect to nature and magnitude. While in the last two decades a large body of evidence demonstrated that smoking is associated with an increased risk of developing complicated CD behavior, need for surgery, and recurr...
This work has been partially funded by fundació miarnau. Author contributions: Tiago Nunes, Maria Jose-fina Etchevers, and Miquel Sans wrote the original article. Tiago Nunes and Miquel Sans performed all statistical analysis. Olga Merino, Sonia Gallego, Valle Garcia, Igna-cio Marín, Luis Menchén, Manuel Barreiro-de Acosta, Guillermo Bastida, Sara ...
- Tiago Nunes, Maria Josefina Etchevers, Olga Merino, Sonia Gallego, Valle García-Sánchez, Ignacio Mar...
- 2013
Feb 2, 2018 · Reigate house fire inquest: Six-year-old Tiago Nunes was killed by one or both of his parents in the deliberately started blaze that wiped out a family. The family of three died instantly when...
tiago nunes da silva. expand_more. Works (22) sort Sort. Clinical and molecular characterization of parathyroid carcinoma in multiple endocrine neoplasia type 1. Endocrine Connections. 2023-08-02 | Journal article | Author. DOI: 10.1530/ec-22-0479.
