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Dec 15, 2022 · Abstract. The development of synthetic strategies for the preparation of bioisosteric compounds is a demanding undertaking in medicinal chemistry. Numerous strategies have been developed for the synthesis of bicyclo [1.1.1]pentanes (BCPs), bridge-substituted BCPs, and bicyclo [2.1.1]hexanes.
4 days ago · Messenger RNAs (mRNAs) have rapidly emerged as a pivotal class of biotherapeutics with great promise in the prevention and treatment of various diseases. As with other biotherapeutics, the sequence accuracy and integrity of mRNAs are critical quality attributes (CQAs), influencing the translation efficiency and protein expression fidelity of mRNAs. Due to the generation of short and repetitive ...
Feb 10, 2023 · Abstract. In contrast to the traditional and widely-used cycloaddition reactions involving at least a π bond component, a [2σ + 2σ] radical cycloaddition between bicyclo [1.1.0]butanes (BCBs) and cyclopropyl ketones has been developed to provide a modular, concise, and atom-economical synthetic route to substituted bicyclo [3.1.1]heptane ...
Christian Merten,[b] and Thorsten Bach[a]* Abstract: In the presence of 1 mol% of a chiral iron porphyrin catalyst, various 3-arylmethyl-substituted 2-quinolones and 2-pyridones underwent an enantioselective amination reaction (20 examples; 93-99% ee). The substrates were used as the limiting reagents, and
Harvey, Freya M.; Heidecker, Alexandra H.; Merten, Christian; Bach, Thorsten: Diastereoselective, Lewis acid-mediated Diels-Alder reactions of allenoic acid derivatives and 1,3-cyclopentadienes. Org. Biomol. Chem. 21, 2023, 4422-4428 more…
May 2, 2024 · Europe PMC is an archive of life sciences journal literature.
May 17, 2023 · Freya M. Harvey, Alexandra H. Heidecker, Christian Merten, Thorsten Bach* Org. Biomol. Chem., 21 (2023) 4422-4428. Morphological profiling identifies the motor protein Eg5 as cellular target of spirooxindoles
