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1. • • Statins are contraindicated in pregnancy because of the perceived increased risk of congenital abnormalities to the foetus. We evaluated the evidence, including published reviews and primary studies, on the safety of statins in pregnancy and assessed the benefits to the mother.
     pubmed.ncbi.nlm.nih.gov/24126785/

     Statins in pregnancy - PubMed

2. People also ask

   Should pregnant women take antihypertensive treatment for chronic hypertension?

   • Offer antihypertensive treatment to pregnant women who have chronic hypertension and who are not already on treatment if they have: When using medicines to treat hypertension in pregnancy, aim for a target blood pressure of 135/85 mmHg. Consider labetalol to treat chronic hypertension in pregnant women.

   Hypertension in pregnancy: diagnosis and management - NICE

   www.nice.org.uk/guidance/ng133/chapter/Recommendations

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   Is statin a contraindication for pregnant women?

   • In July 2021, the US Food and Drug Administration (FDA) requested the removal of the long-standing contraindication to statin use in women who are pregnant or contemplating pregnancy.

   Update on Statin Use in Pregnancy - The American Journal of Medicine

   www.amjmed.com/article/S0002-9343(22)00673-8/fulltext

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   Can I get pregnant with statins If I have hypercholesterolemia?

   • Instead, statins are allowed for women with familial hypercholesterolemia, other severe LDL-C increases, or established (prior) ASCVD whenever the benefits are judged to outweigh any risks. We suggest that inadvertent conception during statin therapy does not require pregnancy termination but should prompt close follow-up with an obstetrician.

   Update on Statin Use in Pregnancy - The American Journal of Medicine

   www.amjmed.com/article/S0002-9343(22)00673-8/fulltext

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   Why are antihypertensive agents used in pregnancy?

   • In this setting, antihypertensive agents are mainly used to prevent and treat severe hypertension; to prolong pregnancy for as long as safely possible, thereby maximizing the gestational age of the infant; and to minimize fetal exposure to medications that may have adverse effects.

   Update on the Use of Antihypertensive Drugs in Pregnancy

   www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.106.075895

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   Can a pregnant woman with FH get a statin deferral?

   • Statin deferral during pregnancy in those with FH is controversial, with some studies suggesting adverse vascular consequences from high cholesterol exposure during the relatively short pregnancy period. Maternal hypercholesterolemia may affect early atherosclerosis development in offspring through complex mechanisms like genetic programming.

   Statin Use in Pregnancy: Is It Time For a Paradigm Shift?

   www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.058983

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   Should pregnant women discontinue statin therapy?

   • The FDA language was likely purposefully vague, allowing latitude in shared decision-making: “Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy.”

   Statin Use in Pregnancy: Is It Time For a Paradigm Shift?

   www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.058983

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3. www.ahajournals.org › doi › fullStatin Use in Pregnancy: Is It Time For a Paradigm Shift?

   www.ahajournals.org › doi › full

   Feb 14, 2022 · Statin deferral during pregnancy in those with FH is controversial, with some studies suggesting adverse vascular consequences from high cholesterol exposure during the relatively short pregnancy period.

   • Update on the Use of Antihypertensive Drugs in Pregnancy

     In this setting, antihypertensive agents are mainly used to...

4. www.ahajournals.org › doi › 10Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals ...

   www.ahajournals.org › doi › 10

   Dec 15, 2021 · Self-measured BP is important for diagnosing nonsustained BP elevations, including masked hypertension and white coat hypertension, that occur before 20 weeks of gestation. For clinical purposes, the definition of hypertension in pregnancy requires 2 elevated BP measurements 4 hours apart (Table S1).

5. www.nice.org.uk › guidance › ng133Hypertension in pregnancy: diagnosis and management - NICE

   www.nice.org.uk › guidance › ng133

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   • 1.1 Reducing the risk of hypertensive disorders in pregnancy. Symptoms of pre-eclampsia. 1.1.1 Advise pregnant women to see a healthcare professional immediately if they experience symptoms of pre-eclampsia.
   • 1.2 Assessment of proteinuria in hypertensive disorders of pregnancy. 1.2.1 Interpret proteinuria measurements for pregnant women in the context of a full clinical review of symptoms, signs and other investigations for pre-eclampsia.
   • 1.3 Management of chronic hypertension in pregnancy. Pre-pregnancy advice. 1.3.1 Offer women with chronic hypertension referral to a specialist in hypertensive disorders of pregnancy to discuss the risks and benefits of treatment.
   • 1.4 Management of gestational hypertension. Assessment and treatment of gestational hypertension. 1.4.1 In women with gestational hypertension, a full assessment should be carried out in a secondary care setting by a healthcare professional who is trained in the management of hypertensive disorders of pregnancy.

6. journals.sagepub.com › doi › fullHypertension in pregnancy: Pathophysiology and treatment

   journals.sagepub.com › doi › full

   Apr 10, 2019 · The most recent Cochrane systematic review of antihypertensive medications for mild to moderate hypertension during pregnancy analyzed 31 trials (3485 women) comparing different antihypertensives to placebo or no treatment, and 29 trials (2774 women) comparing one antihypertensive to another.

   • Author: Stephanie Braunthal, Andrei Brateanu

   • Publish Year: 2019

7. www.nhlbi.nih.gov › news › 2019Chronic hypertension in pregnancy: To treat or not to treat?

   www.nhlbi.nih.gov › news › 2019

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   Sep 16, 2019 · If a woman is pregnant and chronic high blood pressure is seriously high, doctors typically don’t debate what to do. They treat it—and fast—mainly to minimize the risk for strokes and other potentially deadly cardiovascular events.

8. www.ahajournals.org › doi › 10Update on the Use of Antihypertensive Drugs in Pregnancy

   www.ahajournals.org › doi › 10

   Feb 7, 2008 · In this setting, antihypertensive agents are mainly used to prevent and treat severe hypertension; to prolong pregnancy for as long as safely possible, thereby maximizing the gestational age of the infant; and to minimize fetal exposure to medications that may have adverse effects.

9. www.amjmed.com › article › S0002-9343(22)00673-8Update on Statin Use in Pregnancy - The American Journal of ...

   www.amjmed.com › article › S0002-9343(22)00673-8

   Sep 20, 2022 · In July 2021, the US Food and Drug Administration (FDA) requested the removal of the long-standing contraindication to statin use in women who are pregnant or contemplating pregnancy.