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Statins are often prescribed for adults with diabetes because living with diabetes increases the risk of heart attack and stroke. Statins and type 1 diabetes Many people with type 1 diabetes are prescribed a statin to prevent heart disease.
May 27, 2023 · People with prediabetes or diabetes may see their blood sugar levels rise when they start taking a statin. But statins also prevent heart attacks in people with diabetes. The benefit of taking statins likely outweighs the small risk to have the blood sugar level go up.
- One of the most common complaints of people taking statins is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your musc...
- Not everyone who takes a statin will have side effects, but some people may be at a greater risk than are others. Risk factors include: 1. Taking m...
- Grapefruit juice contains a chemical that can interfere with the enzymes that break down (metabolize) the statins in your digestive system. While y...
- It's unclear what causes statin side effects, especially muscle pain.Statins work by slowing your body's production of cholesterol. Your body produ...
- To relieve statin side effects, your doctor may recommend several options. Discuss these steps with your doctor before trying them: 1. Take a brief...
- Although statin side effects can be annoying, consider the benefits of taking a statin before you decide to stop taking your medication. Remember t...
Aug 14, 2024 · Some statin medications come with warnings about increasing your risk for high blood sugar and diabetes. Who’s at risk? And what should you do about it? Find out.
- Overview
- Further information
Statin use may be associated with a level of hyperglycaemia in some patients where formal diabetes care is appropriate.
Article date: January 2012
Statins are one of the most widely prescribed drug classes in Europe for lipid control and cardiovascular prophylaxis, and prescribing is continuing to grow. Between 2002 and 2008 in the UK, statin prevalence has doubled for those older than 40 year and quadrupled for those older than 80 years.
In 2010, a clinical trial meta-analysis reported that statin therapy overall was associated with a slightly increased risk of new onset diabetes (NOD).[footnote 1] Although a small risk (odds ratio 1.09 [95% CI 1.02–1.17]), given the extent of prescribing even a relatively small increase in the risk of NOD could potentially result in a significant number of additional cases of diabetes per year. Treatment of 255 (95% CI 150–852) patients with statins for 4 years resulted in one extra case of diabetes.[footnote 1] However, the evidence suggests that risk depends markedly on individual risk factors.
Comparison of studies across the statin class is limited by numerous factors including differences in patient populations, duration of study, and dose of statin used. Furthermore, the endpoint used to diagnose diabetes varied in terms of frequency and time of analysis, and whether fasting blood glucose or, more rarely, HbA1c levels were measured. Importantly, a recent study[footnote 2] of the association between atorvastatin and NOD suggests that stratification of patients by risk factors may yield different conclusions to those drawn when considering the patient population as a whole.
There is sufficient evidence to support an association between statin use and NOD. However, the risk appears to be mainly in patients already at increased risk of developing diabetes. Raised fasting blood glucose at baseline is a key factor in determining this increased risk and may be sufficient to identify those at risk. Other risk factors include:
BNF section 2.12 Lipid-regulating drugs
1.Sattar N, et al. Lancet 2010; 375: 735–42. ↩ ↩2
2.Waters DD, et al. J Am Coll Cardiol 2011; 57: 1535–45 ↩
3.Preiss D, et al. JAMA 2011; 305: 2556–64. ↩ ↩2
4.The Cholesterol Treatment Trialists’ Collaborators. Lancet 2005; 366: 1267–78. ↩
5.The Cholesterol Treatment Trialists’ Collaborators. Lancet 2008; 371: 117–25. ↩
May 12, 2023 · Statins are associated with a small increased risk of new-onset diabetes, which is higher in people with other risk factors for diabetes, and in association with high intensity statins and older age.
May 15, 2024 · Can statins increase blood sugar? Some research has found that using statins increases blood sugar because statins can stop your body's insulin from working well. This can put people who use statins at higher risk of developing type 2 diabetes.
Mar 27, 2024 · As people at risk for cardiovascular outcomes are also at risk for type 2 diabetes, any prescription of a statin should be accompanied by promoting proven strategies to prevent or delay diabetes, such as modest weight reduction and increased physical activity.
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