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Not only were the two oldest isolates of HIV-1 recuperated from samples obtained in Léopoldville in 1959 and 1960, but molecular studies revealed that the Léopoldville–Brazzaville area har-bours, by far, the highest genetic diversity of HIV-1 group M in the world.11–15 All nine ‘subtypes of HIV-1 group M have. ’.
- Jacques Pépin
- 2013
Sep 1, 2011 · Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses, human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the origins and evolution of...
The acquired immune deficiency syndrome (AIDS) was first formally recognized in patients in the USA in 1981. Subsequent characterization of the principal causative agent, human immunodeficiency virus type 1 (HIV-1), revealed that it was a retrovirus.
to disastrous effect to fuel the spread of the virus from its origins in Léopoldville to the rest of Africa, the Caribbean and ultimately worldwide. This is an essential perspective on HIV/AIDS and on the lessons that must be learned as the world faces another pandemic. Jacques Pépin is Professor in the Department of Microbiology and
Inspired by his own experiences working as an infectious diseases physician in Africa, Jacques Pepin looks back to the early twentieth-century events in Africa that triggered the emergence of HIV/ AIDS (human immunodeficiency virus/acquired immune de ciency syn-. fi.
AIDS virus and its disease. One way to begin searching out the origin of HIV is to look for similar viruses in nonhuman primates. Monkeys and apes are often the only animal species other than human beings that are infected with important human viruses such as yel low fever and Marburg virus; in certain cases it is even thought that wild mon
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HIV-1 group M subtype B was the first HIV discovered and is the predominant variant of AIDS virus in most countries outside of sub-Saharan Africa. However, the circumstances of its origin and emergence remain unresolved. Here we propose a geographic sequence and time line for the origin of subtype B and the emergence of pandemic HIV/AIDS out of ...
