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     • Here, the initiator protein, helicase, recognize and then binds to the origin to unwind the DNA. When the DNA unwinds, two Y-shaped structures called replication forks are formed, together making up the replication bubble. The two forks move in opposite directions as the replication proceeds.
     www.sciencefacts.net/dna-replication.html

     DNA Replication – Definition, Process, Steps, & Labeled Diagram

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   How initiation of DNA replication is coordinated with the eukaryotic cell cycle?

   • Recent results have provided substantial new insights into how the initiation of DNA replication is coordinated with the eukaryotic cell cycle. The replication of the genome of a eukaryotic cell is a tightly regulated process.

   DNA replication: Controlling initiation during the cell cycle

   www.cell.com/current-biology/fulltext/S0960-9822(02)00464-5

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   Which phase of the cell cycle is responsible for initiation of DNA synthesis?

   • ]. During the G1 phase of the cell cycle, the cell becomes competent to initiate DNA synthesis. It is likely that the development of replication competence is associated with the assembly of a multi-protein pre-initiation complex at specific origins of replication.

   DNA replication: Controlling initiation during the cell cycle

   www.cell.com/current-biology/fulltext/S0960-9822(02)00464-5

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   How is DNA replication coordinated with macromolecular synthesis?

   • Firstly, replication is coordinated with general macromolecular synthesis, so that the DNA-to-protein ratio is maintained within a relatively narrow range. This involves a mechanism that couples the initiation of DNA replication to the achievement of a critical cell size. Secondly, replication generates exactly two copies of each DNA segment.

   DNA replication: Controlling initiation during the cell cycle

   www.cell.com/current-biology/fulltext/S0960-9822(02)00464-5

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   How does DNA replication occur in a cell?

   • This is accomplished by the process of DNA replication. The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis. The elucidation of the structure of the double helix provided a hint as to how DNA is copied.

   9.2: DNA Replication - Biology LibreTexts

   bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Concepts_in_Biology_(OpenStax)/09:_Molecular_Biology/9.02:_DNA_Replication

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   What is the mechanism of initiation of DNA replication in yeast?

   • The ORC complex appears to recruit other proteins (including DNA helicases) to the origin, leading to the initiation of replication. The mechanism of initiation of DNA replication in yeasts thus appears similar to that in prokaryotes and eukaryotic viruses; that is, an initiator protein specifically binds to origin sequences.

   DNA Replication - The Cell - NCBI Bookshelf

   www.ncbi.nlm.nih.gov/books/NBK9940/

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   Are replication intermediates formed during initiation of DNA synthesis enriched?

   • Burhans WC, Selegue JE, Heintz NH. Replication intermediates formed during initiation of DNA synthesis in methotrexate-resistant CHOC 400 cells are enriched for sequences from a specific, amplified restriction fragment. Biochemistry. 1986;25:441–449.

   Initiation of DNA Replication in the Human Genome - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC3915928/

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3. teachmephysiology.com › dna-replicationDNA Replication - Stages of Replication - TeachMePhyiology

   teachmephysiology.com › dna-replication

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   Apr 8, 2024 · DNA replication can be thought of in three stages: initiation, elongation and termination. Initiation. DNA synthesis is initiated at particular points within the DNA strand known as ‘ origins ’, which have specific coding regions.

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4. bio.libretexts.org › Bookshelves › Introductory_and9.2: DNA Replication - Biology LibreTexts

   bio.libretexts.org › Bookshelves › Introductory_and

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   Mar 17, 2022 · The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis. The elucidation of the structure of the double helix provided a hint as to how DNA is copied.

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6. www.scienceabc.com › pure-sciences › dna-replicationHow Does DNA Replication Occur? What Are The Enzymes Involved?

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   Jun 2, 2024 · Step 1: Initiation. The point at which the replication begins is known as the Origin of Replication (oriC). Helicase brings about the procedure of strand separation, which leads to the formation of the replication fork. Step 2: Elongation.

   • Author: Vikrant Shetty

   • Video Duration: 5 min

7. www.cell.com › current-biology › fulltextDNA replication: Controlling initiation during the cell cycle

   www.cell.com › current-biology › fulltext

   The replication of the genome of a eukaryotic cell is a tightly regulated process. Firstly, replication is coordinated with general macromolecular synthesis, so that the DNA-to-protein ratio is maintained within a relatively narrow range. This involves a mechanism that couples the initiation of DNA replication to the achievement of a critical ...

   • Author: Marco Muzi-Falconi, Grant W Brown, Thomas J Kelly

   • Publish Year: 1996

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     DNA REPLICATION (1/3) - INITIATION

     29 Aug 2020

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     27:30

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     Stephen P. Bell (MIT / HHMI) 1b: Chromosomal DNA Replication: Initiation of DNA Replication

     15 Feb 2017

     41.2K views

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     4:18

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     Eukaryotic DNA Replication Animation || Formation of Initiation complex

     24 Aug 2022

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9. www.nature.com › articles › nrmicro1640DNA replication initiation: mechanisms and regulation in ...

   www.nature.com › articles › nrmicro1640

   May 1, 2007 · This Review presents an overview of both the mechanism and regulation of bacterial DNA replication initiation, with emphasis on the features that are similar in eukaryotic and archaeal...

   • Author: Melissa L. Mott, James M. Berger

   • Publish Year: 2007

10. www.ncbi.nlm.nih.gov › pmc › articlesInitiation of DNA Replication in the Human Genome - PMC

    www.ncbi.nlm.nih.gov › pmc › articles

    Here we present an overview of the current progress on our understanding of the initiation step of DNA replication in human cells, and its relationship to abnormal cell proliferation.

11. www.ncbi.nlm.nih.gov › books › NBK9940DNA Replication - The Cell - NCBI Bookshelf

    www.ncbi.nlm.nih.gov › books › NBK9940

    The ORC complex appears to recruit other proteins (including DNA helicases) to the origin, leading to the initiation of replication. The mechanism of initiation of DNA replication in yeasts thus appears similar to that in prokaryotes and eukaryotic viruses; that is, an initiator protein specifically binds to origin sequences.