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G1 phase
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- DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding and initiation of DNA synthesis.
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Feb 17, 2023 · DNA replication is the process through which a cell’s DNA forms two exact copies of itself. It occurs in all living organisms as it forms the basis of inheritance in all living organisms. The enzyme carrying out transcription is called DNA polymerase. The primary mechanism of DNA replication is similar across all organisms.
Jun 2, 2024 · The cell initiates the process from a number of points and then the pieces are joined together to create the entire genome! It is important for DNA present in the nucleus to be replicated so that every new cell receives the appropriate number of chromosomes.
- Vikrant Shetty
- 5 min
Apr 8, 2024 · DNA replication, also known as semi-conservative replication, is the process by which DNA is doubled. This is an important process taking place within the dividing cell. In this article, we shall discuss the structure of DNA, the steps involved in DNA replication (initiation, elongation and termination) and the clinical consequences that can ...
Mar 17, 2022 · The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis. The elucidation of the structure of the double helix provided a hint as to how DNA is copied.
Unwinding of DNA at the origin and synthesis of new strands, accommodated by an enzyme known as helicase, results in replication forks growing bi-directionally from the origin. A number of proteins are associated with the replication fork to help in the initiation and continuation of DNA synthesis.
The initiation of DNA replication occurs in two steps. First, a so-called initiator protein unwinds a short stretch of the DNA double helix. Then, a protein known as helicase attaches to and...
Oct 31, 2023 · DNA replication in eukaryotes occurs in three stages: initiation, elongation, and termination, which are aided by several enzymes.