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Apr 8, 2024 · DNA replication can be thought of in three stages: initiation, elongation and termination. Initiation. DNA synthesis is initiated at particular points within the DNA strand known as ‘ origins ’, which have specific coding regions.
Mar 17, 2022 · The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis. The elucidation of the structure of the double helix provided a hint as to how DNA is copied.
The replication of the genome of a eukaryotic cell is a tightly regulated process. Firstly, replication is coordinated with general macromolecular synthesis, so that the DNA-to-protein ratio is maintained within a relatively narrow range. This involves a mechanism that couples the initiation of DNA replication to the achievement of a critical ...
- Marco Muzi-Falconi, Grant W Brown, Thomas J Kelly
- 1996
Jun 2, 2024 · Step 1: Initiation. The point at which the replication begins is known as the Origin of Replication (oriC). Helicase brings about the procedure of strand separation, which leads to the formation of the replication fork. Step 2: Elongation.
- Vikrant Shetty
- 5 min
May 1, 2007 · This Review presents an overview of both the mechanism and regulation of bacterial DNA replication initiation, with emphasis on the features that are similar in eukaryotic and archaeal...
- Melissa L. Mott, James M. Berger
- 2007
ATP builds up when the cell is in a rich medium, triggering DNA replication once the cell has reached a specific size. ATP competes with ADP to bind to DnaA, and the DnaA-ATP complex is able to initiate replication.
The initiation of DNA replication occurs in two steps. First, a so-called initiator protein unwinds a short stretch of the DNA double helix. Then, a protein known as helicase attaches to and...
