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What is DNA replication?
How does DNA replication occur in a cell cycle?
How is DNA replication controlled in eukaryotes?
Where does DNA replication begin?
What is a replication origin?
Why is DNA replication important?
In this section, we discuss how DNA replication is initiated and how cells carefully regulate this process to ensure that it takes place at the proper positions on the chromosome and also at the appropriate time in the life of the cell.
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
- 2002
- 2002
The initiation of DNA replication occurs in two steps. First, a so-called initiator protein unwinds a short stretch of the DNA double helix. Then, a protein known as helicase attaches to...
- Initiation
- Elongation
- Termination
DNA synthesis is initiated at particular points within the DNA strand known as ‘origins’, which have specific coding regions. These origins are targeted by initiator proteins, which go on to recruit more proteins that help aid the replication process, forming a replication complex around the DNA origin. Multiple origin sites exist within the DNA’s ...
Once DNA Polymerase has attached to the two unzipped strands of DNA (i.e. the template strands), it is able to start synthesising new strands of DNA to match the templates. DNA polymerase is only able to extend the primer by adding free nucleotides to the 3’ end. One of the template strands is read in a 3’ to 5’ direction, therefore the new strand ...
The process of expanding the new DNA strands continues until there is either no more DNA template strand left to replicate (i.e. at the end of the chromosome) or two replication forks meet and subsequently terminate.The meeting of two replication forks is not regulated and happens randomly along the course of the chromosome. Once DNA synthesis has ...
Feb 17, 2023 · DNA replication is the process through which a cell’s DNA forms two exact copies of itself. It occurs in all living organisms as it forms the basis of inheritance in all living organisms. The enzyme carrying out transcription is called DNA polymerase. The primary mechanism of DNA replication is similar across all organisms.
Mar 17, 2022 · When a cell divides, it is important that each daughter cell receives an identical copy of the DNA. This is accomplished by the process of DNA replication. The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis.
As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase). The progress of the eukaryotic cell through the cycle is controlled by cell cycle checkpoints .
2 days ago · DNA replication is the process by which the genome’s DNA is copied in cells. Before a cell divides, it must first copy (or replicate) its entire genome so that each resulting daughter cell ends up with its own complete genome.
