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- In eukaryotes, the cell cycle consists of four discrete phases: G 1, S, G 2, and M. The S or synthesis phase is when DNA replication occurs, and the M or mitosis phase is when the cell actually divides.
www.nature.com/scitable/topicpage/eukaryotes-and-cell-cycle-14046014/
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In this section, we discuss how DNA replication is initiated and how cells carefully regulate this process to ensure that it takes place at the proper positions on the chromosome and also at the appropriate time in the life of the cell.
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
- 2002
- 2002
During the G1 phase of the cell cycle, the cell becomes competent to initiate DNA synthesis. It is likely that the development of replication competence is associated with the assembly of a multi-protein pre-initiation complex at specific origins of replication.
- Marco Muzi-Falconi, Grant W Brown, Thomas J Kelly
- 1996
Mar 17, 2022 · The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis. The elucidation of the structure of the double helix provided a hint as to how DNA is copied.
- Initiation
- Elongation
- Termination
DNA synthesis is initiated at particular points within the DNA strand known as ‘origins’, which have specific coding regions. These origins are targeted by initiator proteins, which go on to recruit more proteins that help aid the replication process, forming a replication complex around the DNA origin. Multiple origin sites exist within the DNA’s ...
Once DNA Polymerase has attached to the two unzipped strands of DNA (i.e. the template strands), it is able to start synthesising new strands of DNA to match the templates. DNA polymerase is only able to extend the primer by adding free nucleotides to the 3’ end. One of the template strands is read in a 3’ to 5’ direction, therefore the new strand ...
The process of expanding the new DNA strands continues until there is either no more DNA template strand left to replicate (i.e. at the end of the chromosome) or two replication forks meet and subsequently terminate.The meeting of two replication forks is not regulated and happens randomly along the course of the chromosome. Once DNA synthesis has ...
As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase). The progress of the eukaryotic cell through the cycle is controlled by cell cycle checkpoints .
In the eukaryotic cell cycle, chromosome duplication occurs during "S phase" (the phase of DNA synthesis) and chromosome segregation occurs during "M phase" (the mitosis phase).
The S or synthesis phase is when DNA replication occurs, and the M or mitosis phase is when the cell actually divides. The other two phases — G 1 and G 2, the so-called gap phases — are less...
