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How does initiation of DNA replication occur?
Which phase of the cell cycle is responsible for initiation of DNA synthesis?
How does DNA replication occur in a cell?
How is DNA replication controlled in eukaryotes?
What controls the activation of DNA replication origins?
How initiation of DNA replication is coordinated with the eukaryotic cell cycle?
In this section, we discuss how DNA replication is initiated and how cells carefully regulate this process to ensure that it takes place at the proper positions on the chromosome and also at the appropriate time in the life of the cell.
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
- 2002
- 2002
Mutant cells appear to re-initiate DNA synthesis at origins during a single cell cycle. Moreover, re-initiation occurs despite high levels of Clb-associated Cdk activity.
- Marco Muzi-Falconi, Grant W Brown, Thomas J Kelly
- 1996
Mar 17, 2022 · The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis. The elucidation of the structure of the double helix provided a hint as to how DNA is copied.
- Initiation
- Elongation
- Termination
DNA synthesis is initiated at particular points within the DNA strand known as ‘origins’, which have specific coding regions. These origins are targeted by initiator proteins, which go on to recruit more proteins that help aid the replication process, forming a replication complex around the DNA origin. Multiple origin sites exist within the DNA’s ...
Once DNA Polymerase has attached to the two unzipped strands of DNA (i.e. the template strands), it is able to start synthesising new strands of DNA to match the templates. DNA polymerase is only able to extend the primer by adding free nucleotides to the 3’ end. One of the template strands is read in a 3’ to 5’ direction, therefore the new strand ...
The process of expanding the new DNA strands continues until there is either no more DNA template strand left to replicate (i.e. at the end of the chromosome) or two replication forks meet and subsequently terminate.The meeting of two replication forks is not regulated and happens randomly along the course of the chromosome. Once DNA synthesis has ...
As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase). The progress of the eukaryotic cell through the cycle is controlled by cell cycle checkpoints .
Replication of the human genome relies on the presence of thousands of origins distributed along each of the chromosomes. The activation of these origins occurs in a highly regulated manner to ensure that chromosomes are faithfully duplicated only once during each cell cycle.
May 22, 2015 · Activation of initiation of DNA replication occurs at only a subset of replication origins that were previously assembled in the G1 phase of the cell cycle. This is achieved through a...
