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How does DNA replication occur?
What happens during initiation of a DNA molecule?
What is a replication origin?
Why is DNA replication a highly regulated process?
Jun 2, 2024 · Step 1: Initiation. The point at which the replication begins is known as the Origin of Replication (oriC). Helicase brings about the procedure of strand separation, which leads to the formation of the replication fork. Step 2: Elongation.
- 5 min
Unwinding of DNA at the origin and synthesis of new strands, accommodated by an enzyme known as helicase, results in replication forks growing bi-directionally from the origin. A number of proteins are associated with the replication fork to help in the initiation and continuation of DNA synthesis.
Mar 17, 2022 · The replication of DNA occurs during the synthesis phase, or S phase, of the cell cycle, before the cell enters mitosis or meiosis. The elucidation of the structure of the double helix provided a hint as to how DNA is copied.
Oct 31, 2023 · DNA replication in eukaryotes occurs in three stages: initiation, elongation, and termination, which are aided by several enzymes.
The proteins that initiate DNA replication bind to DNA sequences at a replication origin to catalyze the formation of a replication bubble with two outward-moving replication forks. The process begins when an initiator protein –DNA complex is formed that subsequently loads a DNA helicase onto the DNA template .
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
- 2002
- 2002
The initiation of DNA replication occurs in two steps. First, a so-called initiator protein unwinds a short stretch of the DNA double helix. Then, a protein known as helicase attaches to and...
Initiation and Unwinding. During initiation, so-called initiator proteins bind to the replication origin, a base-pair sequence of nucleotides known as oriC. This binding triggers events that...
